Suppression of mouse islet NOS activity (by L-NAME, L-NMMA, or 7-nitroindazole), is accompanied by an increase in GSIS (Panagiotidis et al., 1995[100]; Akesson et al., 1999[1]; Henningsson et al., 2000[49], 2002[52]; Eckersten and Henningsson, 2012[28]), indicating the negative role of NO in insulin secretion. In addition, GSIS has been shown to be suppressed by different concentrations of NO donors in isolated mouse (Panagiotidis et al., 1995[100]; Akesson and Lundquist, 1999[2]) and rat (Antoine et al., 1996[5]) pancreatic islets.