Besides extracellular biomimetic nanomaterials, supramolecular assemblies are able to mimic intracellular biomacromolecules for enzyme sequestration. For example, a phosphopeptide precursor (7) targeting ER undergoes dephosphorylation and forms nanofibers of 8 that sequestrate enzymes enriched in ER (Figure 2B(Fig. 2)) (Feng et al., 2018[23]). A trimethylated phosphopeptide undergoes ALP-instructed intracellular morphological transition to form bundles of artificial filaments inside the cells (Feng et al., 2020[21]). The biomimetic filaments hardly interfere with endogenous compartments, providing insights for intracellular filaments engineering.