This study was supported by the Basic Science Research Program Planning (NRF-2018R1A2B3003868 and NRF-2017R1A5A1014560) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning and by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI20C0026).