The conjunctiva is a mucosal tissue composed of three layers: the conjunctival epithelial layer, goblet cell layer, and lamina propria. The lamina propria is the site where immune cells reside and produces immunoregulatory factors. In the conjunctiva, several immune responses, such as antigen processing, cell-mediated immunity, and hypersensitivity, occur104. The conjunctiva exhibits basal expression of FPR1 and FPR2, and FPR1 and FPR2 expression is elevated in the setting of inflammation, such as in allergic conditions103. FPR2 is expressed on conjunctival goblet cells and increases mucin production by recognizing LXA4 and RvD196,107. Intracellular calcium influx is directly related to glycoconjugate secretion, and the LXA4-FPR2 axis can promote mucin secretion via calcium influx96. Various downstream signaling molecules of FPR2 affect calcium influx, which shows that FPR2 signaling and homeostasis of the ocular environment are closely related107.