Funding Information This paper was supported by the following grants: http://dx.doi.org/10.13039/501100000925National Health and Medical Research Council GNT0631947 to Robyn McDermott. http://dx.doi.org/10.13039/501100000925National Health and Medical Research Council to Geraint Rogers. Acknowledgements This work was supported by the National Health and Medical Research Council [grant number GNT0631947]. The salary of KLI was supported by a National Health and Medical Research Council fellowship and GBR was supported by a Matthew Flinders Research Fellowship and a National Health and Medical Research Council Senior Research Fellowship. The Zenadth Kes Health Partnership Project was made possible by the contribution of many people, including the diligent team from Torres and Cape Hospital and Health Service, James Cook University staff and students, Waiben and Mer community members, and the many people that generously gave their time to participate in the study. Additional information Competing interests No competing interests declared. Author contributions Data curation, Formal analysis, Writing - original draft. Data curation, Formal analysis, Writing - review and editing. Data curation, Project administration, Writing - review and editing. Data curation, Project administration, Writing - review and editing. Data curation, Project administration, Writing - review and editing. Formal analysis, Writing - review and editing. Writing - review and editing. Writing - review and editing. Project administration, Writing - review and editing. Conceptualization, Writing - original draft, Writing - review and editing. Conceptualization, Writing - original draft, Project administration, Writing - review and editing. Ethics Human subjects: In addition to the health check that was a standard component of the WPHC, participants consented to have additional health data collected for research purposes. Verbal consent was used whenever a written one could not be obtained. In addition to individual consent, parent/legal guardian consent was obtained for all participants younger than 18 years. The study was granted ethical approval by the Far North Queensland Human Research Ethics Committee (HREC/16/QCH/70-1059). In addition, written support from the local Community Council, Primary Health Care Service and TCHHS was also provided. Additional files Supplementary file 1. Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities: Supplementary files. Transparent reporting form Reporting standard 1. STROBE checklist. Data availability Shotgun metagenomic sequence data reported in this study were submitted to the National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA) archive and are publicly available via the accession numbers SRA: SRP167939 and BioProject: PRJNA503909. The following dataset was generated: Mobegi F 2018 Torres Strait Islands Health Surveys, 2016 NCBI BioProject PRJNA503909