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PMC:7571312 / 94806-95846 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T659 385-386 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T660 541-542 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T661 931-933 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T662 968-973 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1836 77-83 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T1837 86-89 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1838 120-126 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1840 127-133 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1841 134-139 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1842 140-148 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1843 150-163 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T1844 167-174 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1846 175-184 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1847 175-177 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1848 178-184 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1849 187-198 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1851 216-218 Chemical denotes N2 http://purl.obolibrary.org/obo/CHEBI_17997
T1852 220-239 Chemical denotes tert-butoxycarbonyl http://purl.obolibrary.org/obo/CHEBI_48502
T1853 252-258 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T1854 261-264 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1855 295-301 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1857 302-308 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1858 312-318 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1860 472-480 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1861 481-491 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T1862 556-558 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1863 564-568 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T1864 585-587 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1865 609-611 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1866 633-635 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1867 647-649 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1868 661-663 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1869 685-687 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1870 709-711 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1871 733-735 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1872 761-763 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1873 775-777 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1874 817-819 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1875 831-833 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1876 845-847 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1877 931-933 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T543 0-405 Sentence denotes Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-5-methyl-l-norleucinamide and making no other critical variations provided a crude yellow foam.
T544 406-555 Sentence denotes This material was purified by Biotage MPLC (25 M column, 2.5–3.5% methanol/chloroform) to afford 307 mg (73%) of the title compound as a white solid.
T545 556-1040 Sentence denotes 1H NMR (DMSO-d6) δ 11.57 (s, 1H), 8.59 (d, J = 8 Hz, 1H), 8.41 (d, J = 4 Hz, 1H), 7.64 (s, 1H), 7.37 (s, 1H), 7.09 (t, J = 8 Hz, 1H), 7.00 (d, J = 8 Hz, 1H), 6.49 (d, J = 8 Hz, 1H), 4.59 (s, 2H), 4.44 (m, 1H), 4.35 (m, 1H), 3.87 (s, 3H), 3.08 (m, 2H), 2.26 (m, 1H), 2.07 (m, 1H), 1.98 (m, 1H), 1.70–1.51 (m, 5H), 1.25 (m, 2H), 0.88 (d, J = 4 Hz, 3H), 0.86 (d, J = 4 Hz, 3H); MS (ESI+) for C25H33ClN4O5m/z 505.2 (M + H)+; HRMS (ESI+) calcd for C25H33ClN4O5+H1 505.2212, found 505.2204.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1838 1009-1014 Species denotes O5+H1 Tax:2491878
1839 472-480 Chemical denotes methanol MESH:D000432
1840 481-491 Chemical denotes chloroform MESH:D002725
1841 977-981 Disease denotes HRMS