PMC:7571312 / 77716-78112 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T579","span":{"begin":376,"end":377},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-4-methyl-l-leucinamide and making noncritical variations provided a pale yellow solid."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1073","span":{"begin":77,"end":83},"obj":"Chemical"},{"id":"T1074","span":{"begin":86,"end":89},"obj":"Chemical"},{"id":"T1075","span":{"begin":120,"end":126},"obj":"Chemical"},{"id":"T1077","span":{"begin":127,"end":133},"obj":"Chemical"},{"id":"T1078","span":{"begin":134,"end":139},"obj":"Chemical"},{"id":"T1079","span":{"begin":140,"end":148},"obj":"Chemical"},{"id":"T1080","span":{"begin":150,"end":163},"obj":"Chemical"},{"id":"T1081","span":{"begin":167,"end":174},"obj":"Chemical"},{"id":"T1083","span":{"begin":175,"end":184},"obj":"Chemical"},{"id":"T1084","span":{"begin":175,"end":177},"obj":"Chemical"},{"id":"T1085","span":{"begin":178,"end":184},"obj":"Chemical"},{"id":"T1086","span":{"begin":187,"end":198},"obj":"Chemical"},{"id":"T1088","span":{"begin":216,"end":218},"obj":"Chemical"},{"id":"T1089","span":{"begin":220,"end":239},"obj":"Chemical"},{"id":"T1090","span":{"begin":252,"end":258},"obj":"Chemical"},{"id":"T1091","span":{"begin":261,"end":264},"obj":"Chemical"},{"id":"T1092","span":{"begin":295,"end":301},"obj":"Chemical"},{"id":"T1094","span":{"begin":302,"end":308},"obj":"Chemical"},{"id":"T1095","span":{"begin":312,"end":318},"obj":"Chemical"}],"attributes":[{"id":"A1073","pred":"chebi_id","subj":"T1073","obj":"http://purl.obolibrary.org/obo/CHEBI_47853"},{"id":"A1074","pred":"chebi_id","subj":"T1074","obj":"http://purl.obolibrary.org/obo/CHEBI_46629"},{"id":"A1075","pred":"chebi_id","subj":"T1075","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A1076","pred":"chebi_id","subj":"T1075","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A1077","pred":"chebi_id","subj":"T1077","obj":"http://purl.obolibrary.org/obo/CHEBI_26308"},{"id":"A1078","pred":"chebi_id","subj":"T1078","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A1079","pred":"chebi_id","subj":"T1079","obj":"http://purl.obolibrary.org/obo/CHEBI_23019"},{"id":"A1080","pred":"chebi_id","subj":"T1080","obj":"http://purl.obolibrary.org/obo/CHEBI_30359"},{"id":"A1081","pred":"chebi_id","subj":"T1081","obj":"http://purl.obolibrary.org/obo/CHEBI_32772"},{"id":"A1082","pred":"chebi_id","subj":"T1081","obj":"http://purl.obolibrary.org/obo/CHEBI_44520"},{"id":"A1083","pred":"chebi_id","subj":"T1083","obj":"http://purl.obolibrary.org/obo/CHEBI_16881"},{"id":"A1084","pred":"chebi_id","subj":"T1084","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A1085","pred":"chebi_id","subj":"T1085","obj":"http://purl.obolibrary.org/obo/CHEBI_35581"},{"id":"A1086","pred":"chebi_id","subj":"T1086","obj":"http://purl.obolibrary.org/obo/CHEBI_23004"},{"id":"A1087","pred":"chebi_id","subj":"T1086","obj":"http://purl.obolibrary.org/obo/CHEBI_37622"},{"id":"A1088","pred":"chebi_id","subj":"T1088","obj":"http://purl.obolibrary.org/obo/CHEBI_17997"},{"id":"A1089","pred":"chebi_id","subj":"T1089","obj":"http://purl.obolibrary.org/obo/CHEBI_48502"},{"id":"A1090","pred":"chebi_id","subj":"T1090","obj":"http://purl.obolibrary.org/obo/CHEBI_47853"},{"id":"A1091","pred":"chebi_id","subj":"T1091","obj":"http://purl.obolibrary.org/obo/CHEBI_46629"},{"id":"A1092","pred":"chebi_id","subj":"T1092","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A1093","pred":"chebi_id","subj":"T1092","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A1094","pred":"chebi_id","subj":"T1094","obj":"http://purl.obolibrary.org/obo/CHEBI_26308"},{"id":"A1095","pred":"chebi_id","subj":"T1095","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A1096","pred":"chebi_id","subj":"T1095","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"}],"text":"Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-4-methyl-l-leucinamide and making noncritical variations provided a pale yellow solid."}

{"project":"LitCovid-sentences","denotations":[{"id":"T470","span":{"begin":0,"end":396},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-4-methyl-l-leucinamide and making noncritical variations provided a pale yellow solid."}