PMC:7571312 / 5377-5766 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T62466","span":{"begin":17,"end":22},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T96017","span":{"begin":158,"end":159},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T76689","span":{"begin":185,"end":187},"obj":"http://purl.obolibrary.org/obo/CLO_0008285"}],"text":"sons made to the human rhinovirus (HRV) 3Cpro.28 Although these two proteases share very little sequence conservation, the substrate consensus sequences have a Gln residue in common at P1. Analysis of the HRV 3Cpro crystal structure with 1 (rupintrivir; Figure 2) revealed binding interactions that are like those observed for 1 bound to TGEV 3CLpro, which was used in the construction of "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T53","span":{"begin":160,"end":163},"obj":"Chemical"},{"id":"T54","span":{"begin":185,"end":187},"obj":"Chemical"}],"attributes":[{"id":"A53","pred":"chebi_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/CHEBI_30011"},{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_60949"}],"text":"sons made to the human rhinovirus (HRV) 3Cpro.28 Although these two proteases share very little sequence conservation, the substrate consensus sequences have a Gln residue in common at P1. Analysis of the HRV 3Cpro crystal structure with 1 (rupintrivir; Figure 2) revealed binding interactions that are like those observed for 1 bound to TGEV 3CLpro, which was used in the construction of "}

{"project":"LitCovid-PubTator","denotations":[{"id":"145","span":{"begin":17,"end":33},"obj":"Species"},{"id":"146","span":{"begin":338,"end":342},"obj":"Species"},{"id":"148","span":{"begin":35,"end":38},"obj":"Species"},{"id":"149","span":{"begin":205,"end":208},"obj":"Species"},{"id":"150","span":{"begin":160,"end":163},"obj":"Chemical"},{"id":"151","span":{"begin":241,"end":252},"obj":"Chemical"}],"attributes":[{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"Tax:169066"},{"id":"A146","pred":"tao:has_database_id","subj":"146","obj":"Tax:11149"},{"id":"A148","pred":"tao:has_database_id","subj":"148","obj":"Tax:169066"},{"id":"A149","pred":"tao:has_database_id","subj":"149","obj":"Tax:169066"},{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"MESH:D005973"},{"id":"A151","pred":"tao:has_database_id","subj":"151","obj":"MESH:C118874"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"sons made to the human rhinovirus (HRV) 3Cpro.28 Although these two proteases share very little sequence conservation, the substrate consensus sequences have a Gln residue in common at P1. Analysis of the HRV 3Cpro crystal structure with 1 (rupintrivir; Figure 2) revealed binding interactions that are like those observed for 1 bound to TGEV 3CLpro, which was used in the construction of "}

{"project":"2_test","denotations":[{"id":"33054210-12746549-61913453","span":{"begin":46,"end":48},"obj":"12746549"}],"text":"sons made to the human rhinovirus (HRV) 3Cpro.28 Although these two proteases share very little sequence conservation, the substrate consensus sequences have a Gln residue in common at P1. Analysis of the HRV 3Cpro crystal structure with 1 (rupintrivir; Figure 2) revealed binding interactions that are like those observed for 1 bound to TGEV 3CLpro, which was used in the construction of "}