PMC:7571312 / 4572-4838 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T65970","span":{"begin":70,"end":72},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T92074","span":{"begin":264,"end":266},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"}],"text":"Orientation and stabilization of the acyloxy leaving group within the S1′ domain (Figure 1) of the protease can facilitate SN2 displacement via sulfur migration, resulting in irreversible or bimodal (reversible inhibition followed by slow inactivation) inhibition.27"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T42","span":{"begin":53,"end":58},"obj":"Chemical"},{"id":"T43","span":{"begin":144,"end":150},"obj":"Chemical"}],"attributes":[{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_26833"}],"text":"Orientation and stabilization of the acyloxy leaving group within the S1′ domain (Figure 1) of the protease can facilitate SN2 displacement via sulfur migration, resulting in irreversible or bimodal (reversible inhibition followed by slow inactivation) inhibition.27"}

{"project":"LitCovid-sentences","denotations":[{"id":"T19","span":{"begin":0,"end":266},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Orientation and stabilization of the acyloxy leaving group within the S1′ domain (Figure 1) of the protease can facilitate SN2 displacement via sulfur migration, resulting in irreversible or bimodal (reversible inhibition followed by slow inactivation) inhibition.27"}

{"project":"LitCovid-PubTator","denotations":[{"id":"129","span":{"begin":123,"end":126},"obj":"Gene"},{"id":"133","span":{"begin":144,"end":150},"obj":"Chemical"}],"attributes":[{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"Gene:92745"},{"id":"A133","pred":"tao:has_database_id","subj":"133","obj":"MESH:D013455"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Orientation and stabilization of the acyloxy leaving group within the S1′ domain (Figure 1) of the protease can facilitate SN2 displacement via sulfur migration, resulting in irreversible or bimodal (reversible inhibition followed by slow inactivation) inhibition.27"}

{"project":"2_test","denotations":[{"id":"33054210-10353641-61913452","span":{"begin":264,"end":266},"obj":"10353641"}],"text":"Orientation and stabilization of the acyloxy leaving group within the S1′ domain (Figure 1) of the protease can facilitate SN2 displacement via sulfur migration, resulting in irreversible or bimodal (reversible inhibition followed by slow inactivation) inhibition.27"}