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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T24320","span":{"begin":41,"end":49},"obj":"Body_part"},{"id":"T27359","span":{"begin":326,"end":334},"obj":"Body_part"},{"id":"T53411","span":{"begin":413,"end":420},"obj":"Body_part"}],"attributes":[{"id":"A82323","pred":"fma_id","subj":"T24320","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A60926","pred":"fma_id","subj":"T27359","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A10236","pred":"fma_id","subj":"T53411","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"There are numerous reports of reversible cysteine protease inhibitors, which include aldehydes,10−13 thio- or oxymethylketones,14 cyclic ketones,15 amidomethylketones,16 nitriles,17,18 or various 1,2-dicarbonyl motifs.19,20 The electrophilic carbon of these chemotypes reacts reversibly with the sulfur atom of an active-site cysteine forming a covalently bound tetrahedral complex. Stabilization of this charged protein–ligand transition state by an “oxyanion hole” present in the active site has been observed with certain inhibitor classes by X-ray crystallography and NMR.21,22 A recent report describes the optimization of a series of peptidomimetics designed with an α-ketoamide warhead, which achieves broad-spectrum inhibition against the Mpro for several coronaviruses and enteroviruses. Importantly, the reported protease potencies correlate to antiviral potencies, and the authors suggest that the reported SARS CoV-1 3CLpro activity of their lead could be predictive of the SARS CoV-2 3CLpro activity.23"}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T28","span":{"begin":918,"end":922},"obj":"Disease"},{"id":"T29","span":{"begin":986,"end":990},"obj":"Disease"}],"attributes":[{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"There are numerous reports of reversible cysteine protease inhibitors, which include aldehydes,10−13 thio- or oxymethylketones,14 cyclic ketones,15 amidomethylketones,16 nitriles,17,18 or various 1,2-dicarbonyl motifs.19,20 The electrophilic carbon of these chemotypes reacts reversibly with the sulfur atom of an active-site cysteine forming a covalently bound tetrahedral complex. Stabilization of this charged protein–ligand transition state by an “oxyanion hole” present in the active site has been observed with certain inhibitor classes by X-ray crystallography and NMR.21,22 A recent report describes the optimization of a series of peptidomimetics designed with an α-ketoamide warhead, which achieves broad-spectrum inhibition against the Mpro for several coronaviruses and enteroviruses. Importantly, the reported protease potencies correlate to antiviral potencies, and the authors suggest that the reported SARS CoV-1 3CLpro activity of their lead could be predictive of the SARS CoV-2 3CLpro activity.23"}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T55317","span":{"begin":314,"end":320},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T10101","span":{"begin":343,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T44241","span":{"begin":482,"end":488},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T14318","span":{"begin":494,"end":497},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T44972","span":{"begin":582,"end":583},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T86707","span":{"begin":628,"end":629},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T48673","span":{"begin":936,"end":944},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T59338","span":{"begin":1004,"end":1012},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"There are numerous reports of reversible cysteine protease inhibitors, which include aldehydes,10−13 thio- or oxymethylketones,14 cyclic ketones,15 amidomethylketones,16 nitriles,17,18 or various 1,2-dicarbonyl motifs.19,20 The electrophilic carbon of these chemotypes reacts reversibly with the sulfur atom of an active-site cysteine forming a covalently bound tetrahedral complex. Stabilization of this charged protein–ligand transition state by an “oxyanion hole” present in the active site has been observed with certain inhibitor classes by X-ray crystallography and NMR.21,22 A recent report describes the optimization of a series of peptidomimetics designed with an α-ketoamide warhead, which achieves broad-spectrum inhibition against the Mpro for several coronaviruses and enteroviruses. Importantly, the reported protease potencies correlate to antiviral potencies, and the authors suggest that the reported SARS CoV-1 3CLpro activity of their lead could be predictive of the SARS CoV-2 3CLpro activity.23"}

LitCovid-PD-CHEBI

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T14","span":{"begin":0,"end":382},"obj":"Sentence"},{"id":"T15","span":{"begin":383,"end":796},"obj":"Sentence"},{"id":"T16","span":{"begin":797,"end":1015},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"There are numerous reports of reversible cysteine protease inhibitors, which include aldehydes,10−13 thio- or oxymethylketones,14 cyclic ketones,15 amidomethylketones,16 nitriles,17,18 or various 1,2-dicarbonyl motifs.19,20 The electrophilic carbon of these chemotypes reacts reversibly with the sulfur atom of an active-site cysteine forming a covalently bound tetrahedral complex. Stabilization of this charged protein–ligand transition state by an “oxyanion hole” present in the active site has been observed with certain inhibitor classes by X-ray crystallography and NMR.21,22 A recent report describes the optimization of a series of peptidomimetics designed with an α-ketoamide warhead, which achieves broad-spectrum inhibition against the Mpro for several coronaviruses and enteroviruses. Importantly, the reported protease potencies correlate to antiviral potencies, and the authors suggest that the reported SARS CoV-1 3CLpro activity of their lead could be predictive of the SARS CoV-2 3CLpro activity.23"}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"102","span":{"begin":747,"end":751},"obj":"Gene"},{"id":"103","span":{"begin":41,"end":58},"obj":"Gene"},{"id":"104","span":{"begin":764,"end":777},"obj":"Species"},{"id":"105","span":{"begin":918,"end":926},"obj":"Species"},{"id":"106","span":{"begin":986,"end":996},"obj":"Species"},{"id":"107","span":{"begin":85,"end":94},"obj":"Chemical"},{"id":"108","span":{"begin":97,"end":126},"obj":"Chemical"},{"id":"109","span":{"begin":130,"end":144},"obj":"Chemical"},{"id":"110","span":{"begin":148,"end":166},"obj":"Chemical"},{"id":"111","span":{"begin":170,"end":178},"obj":"Chemical"},{"id":"112","span":{"begin":196,"end":210},"obj":"Chemical"},{"id":"113","span":{"begin":242,"end":248},"obj":"Chemical"},{"id":"114","span":{"begin":296,"end":302},"obj":"Chemical"},{"id":"115","span":{"begin":326,"end":334},"obj":"Chemical"},{"id":"116","span":{"begin":673,"end":684},"obj":"Chemical"},{"id":"117","span":{"begin":685,"end":692},"obj":"Chemical"}],"attributes":[{"id":"A102","pred":"tao:has_database_id","subj":"102","obj":"Gene:8673700"},{"id":"A103","pred":"tao:has_database_id","subj":"103","obj":"Gene:1508"},{"id":"A104","pred":"tao:has_database_id","subj":"104","obj":"Tax:11118"},{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"Tax:694009"},{"id":"A106","pred":"tao:has_database_id","subj":"106","obj":"Tax:2697049"},{"id":"A107","pred":"tao:has_database_id","subj":"107","obj":"MESH:D000447"},{"id":"A111","pred":"tao:has_database_id","subj":"111","obj":"MESH:D009570"},{"id":"A113","pred":"tao:has_database_id","subj":"113","obj":"MESH:D002244"},{"id":"A114","pred":"tao:has_database_id","subj":"114","obj":"MESH:D013455"},{"id":"A115","pred":"tao:has_database_id","subj":"115","obj":"MESH:D003545"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"There are numerous reports of reversible cysteine protease inhibitors, which include aldehydes,10−13 thio- or oxymethylketones,14 cyclic ketones,15 amidomethylketones,16 nitriles,17,18 or various 1,2-dicarbonyl motifs.19,20 The electrophilic carbon of these chemotypes reacts reversibly with the sulfur atom of an active-site cysteine forming a covalently bound tetrahedral complex. Stabilization of this charged protein–ligand transition state by an “oxyanion hole” present in the active site has been observed with certain inhibitor classes by X-ray crystallography and NMR.21,22 A recent report describes the optimization of a series of peptidomimetics designed with an α-ketoamide warhead, which achieves broad-spectrum inhibition against the Mpro for several coronaviruses and enteroviruses. Importantly, the reported protease potencies correlate to antiviral potencies, and the authors suggest that the reported SARS CoV-1 3CLpro activity of their lead could be predictive of the SARS CoV-2 3CLpro activity.23"}

2_test

{"project":"2_test","denotations":[{"id":"33054210-9667969-61913444","span":{"begin":95,"end":97},"obj":"9667969"},{"id":"33054210-7794931-61913445","span":{"begin":98,"end":100},"obj":"7794931"},{"id":"33054210-12270191-61913446","span":{"begin":145,"end":147},"obj":"12270191"},{"id":"33054210-8230139-61913447","span":{"begin":218,"end":220},"obj":"8230139"},{"id":"33054210-11848867-61913448","span":{"begin":576,"end":578},"obj":"11848867"},{"id":"33054210-32045235-61913449","span":{"begin":1013,"end":1015},"obj":"32045235"}],"text":"There are numerous reports of reversible cysteine protease inhibitors, which include aldehydes,10−13 thio- or oxymethylketones,14 cyclic ketones,15 amidomethylketones,16 nitriles,17,18 or various 1,2-dicarbonyl motifs.19,20 The electrophilic carbon of these chemotypes reacts reversibly with the sulfur atom of an active-site cysteine forming a covalently bound tetrahedral complex. Stabilization of this charged protein–ligand transition state by an “oxyanion hole” present in the active site has been observed with certain inhibitor classes by X-ray crystallography and NMR.21,22 A recent report describes the optimization of a series of peptidomimetics designed with an α-ketoamide warhead, which achieves broad-spectrum inhibition against the Mpro for several coronaviruses and enteroviruses. Importantly, the reported protease potencies correlate to antiviral potencies, and the authors suggest that the reported SARS CoV-1 3CLpro activity of their lead could be predictive of the SARS CoV-2 3CLpro activity.23"}