Supporting Information Available
The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01063.Molecular formula strings for all compounds with biological data (CSV)
HPLC purity for compound 4 (PDF)

Supplementary Material
jm0c01063_si_001.csv
jm0c01063_si_002.pdf

Author Contributions
The manuscript was written through the contributions of all authors. All authors have given approval to the final version of the manuscript.

Funding for the antiviral testing was provided by NIAID under a cooperative agreement between NIAID and Pfizer.

The authors declare no competing financial interest.

Acknowledgments
The authors would like to thank the Pfizer La Jolla Discovery Technology group who were responsible for all HRMS, preparative HPLC, and SFC separations. Antiviral testing was performed at the Southern Research Institute (Birmingham, AL). The authors wish to thank Dr. Heinz Feldman (NIAID, Hamilton, MT) for the kind gift of the SARS CoV Toronto-2 cell line enabling this testing. The authors wish to thank Cathy Laughlin, Christopher Tseng, and Jack Secrist for their roles in this collaboration. The authors would also like to thank Kevin Freeman-Cook, Charlotte Allerton, and Gina M. Yanochko-Hoffman for critically reading the manuscript and offering valued editing suggestions.