PMC:7571312 / 10227-10619 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T8217","span":{"begin":244,"end":245},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T52201","span":{"begin":286,"end":287},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T96491","span":{"begin":330,"end":331},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Central to our strategy of examining ketone-based thiophiles was the preparation of an array of intermediates containing diverse methylketone moieties and protecting groups. The preparation of halomethylketone intermediates was accomplished in a two-step procedure by the generation of a diazoketone intermediate31 or directly by a modified Kowalski–Haque reaction,32 as depicted in Scheme 1."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T123","span":{"begin":37,"end":43},"obj":"Chemical"}],"attributes":[{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_17087"}],"text":"Central to our strategy of examining ketone-based thiophiles was the preparation of an array of intermediates containing diverse methylketone moieties and protecting groups. The preparation of halomethylketone intermediates was accomplished in a two-step procedure by the generation of a diazoketone intermediate31 or directly by a modified Kowalski–Haque reaction,32 as depicted in Scheme 1."}

{"project":"LitCovid-sentences","denotations":[{"id":"T51","span":{"begin":0,"end":173},"obj":"Sentence"},{"id":"T52","span":{"begin":174,"end":392},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Central to our strategy of examining ketone-based thiophiles was the preparation of an array of intermediates containing diverse methylketone moieties and protecting groups. The preparation of halomethylketone intermediates was accomplished in a two-step procedure by the generation of a diazoketone intermediate31 or directly by a modified Kowalski–Haque reaction,32 as depicted in Scheme 1."}

{"project":"LitCovid-PubTator","denotations":[{"id":"258","span":{"begin":37,"end":43},"obj":"Chemical"},{"id":"259","span":{"begin":129,"end":141},"obj":"Chemical"},{"id":"260","span":{"begin":193,"end":209},"obj":"Chemical"},{"id":"261","span":{"begin":288,"end":299},"obj":"Chemical"}],"attributes":[{"id":"A258","pred":"tao:has_database_id","subj":"258","obj":"MESH:D007659"},{"id":"A259","pred":"tao:has_database_id","subj":"259","obj":"MESH:D000096"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Central to our strategy of examining ketone-based thiophiles was the preparation of an array of intermediates containing diverse methylketone moieties and protecting groups. The preparation of halomethylketone intermediates was accomplished in a two-step procedure by the generation of a diazoketone intermediate31 or directly by a modified Kowalski–Haque reaction,32 as depicted in Scheme 1."}

{"project":"2_test","denotations":[{"id":"33054210-1433192-61913455","span":{"begin":312,"end":314},"obj":"1433192"},{"id":"33054210-10746010-61913456","span":{"begin":365,"end":367},"obj":"10746010"}],"text":"Central to our strategy of examining ketone-based thiophiles was the preparation of an array of intermediates containing diverse methylketone moieties and protecting groups. The preparation of halomethylketone intermediates was accomplished in a two-step procedure by the generation of a diazoketone intermediate31 or directly by a modified Kowalski–Haque reaction,32 as depicted in Scheme 1."}