We conclude that the incidence of putative IPA may be high in patients with COVID-19 and that chronic obstructive pulmonary disease may be a particular risk factor. Implementation of surveillance of mechanically ventilated patients with COVID-19 using the nondirected BAL technique is feasible. As COVID-19–associated IPA appears to resemble influenza-associated IPA in many ways, and ICU length of stay was longer in those with IPA versus those without, it is our opinion that active surveillance and treatment may be beneficial in patients with COVID-19.