Early detection and treatment of IPA improves outcome compared with delayed diagnosis. Therefore, we opted to treat all nine patients who were deemed to have putative IPA with antifungal therapy (with an empirical regimen consisting of amphotericin B and voriconazole). We noted a longer ICU length of stay for patients who developed IPA, although ICU mortality did not differ between groups. However, whether COVID-19–associated IPA contributes to mortality, or whether IPA therapy improves outcome, cannot be dissected from our study.