There are hundreds of clinical protocols around the world adapted locally to patient characteristics, prevention measures, diagnostic tests, availability of potential therapy options, and possibility of follow-up. The use of clinical protocols in health care aims to provide practitioners with locally agreed information about what is currently the recommended approach for a specific practice. Such protocols should be systematically developed and based on an evaluation of the current best evidence. Thus, they also have the potential advantage of reducing unnecessary variations in care and contributing to evidence-based health care [5]. Based on this premise, we conducted this study, whose main objective was to compare updated clinical protocols for treatment of COVID-19 among the largest university hospitals in Andalusia, Spain. We hypothesized that clinical protocols could vary in several aspects among Andalusian Hospitals, regardless of whether they belong to the same local health system administration and have similar resources.