In conclusion, this study showed that the COVID-19 protocols of the largest hospitals in Andalusia, Spain, varied widely in several aspects, including antiviral treatment; corticosteroids; anakinra; prophylactic heparin for patients at high risk of thrombosis; therapeutic doses of heparin for patients in critical condition or with a progressive increase in D-dimer levels; and different dosage, duration, and combinations of treatment for patients in the same clinical condition.