This study has several limitations. First, we only analyzed the data provided in the hospitals’ treatment protocols, and no information on treated actually provided to patients was obtained. Furthermore, we did not know the degree of protocol implementation in the hospital or its coverage area. Second, only the protocols of the largest hospitals of Andalusia were analyzed in this study, even though there are many smaller hospitals and healthcare centers. Normally, the treatment recommendations adopted in reference hospitals indicate how their area of influence proceeds, but this cannot be definitively assured. Third, our study focused only on adult patients, and the recommendations were not applicable to pediatric populations. Finally, the recommendations provided in the protocols are based on local expert opinions, clinical experience in managing COVID-19 patients, and current international evidence regarding major proposed treatments, whether repurposed or experimental, for COVID-19. Therefore, no strong therapeutic recommendations could be drawn from the protocols analyzed in this study.