These results are important because they show significant differences among the recommended treatments for COVID-19, according to the treatment protocols of large university hospitals in a region of Spain. They reveal a need for specifically designed randomized clinical trials to determine the most appropriate evidence-based treatment regimen. COVID-19 is having a strong impact in several countries, including Spain, in several aspects, especially health, economic, and social. There is a quickly growing body of evidence on this topic trying to find the best practice for the treatment of symptomatic patients with COVID-19 [37].