a very suitable approach for this task, especially the facts that it can work with noncrystalline samples and, to a certain degree, those with structural flexibility (Dashti et al., 2014 ▸; Maji et al., 2020 ▸; Scheres et al., 2007 ▸; Sorzano et al., 2019 ▸; Tagare et al., 2