In the present study, the significant impact of COVID-19 pandemic confinement on air quality in studied locations was determined by right-tailed, Welch’s two-sample t test. The complete data set was divided into two groups, pre-confinement (A) and during confinement (B) to assess if there is a statistically significant effect of confinement on AQI. Independent random samples of sizes n1, n2 were drawn by using a random number table from both the groups and applied t test using the R-software. This inferential statistic was used to test the following hypothesis:H0: No significant difference between the means of two groups i.e., no significant effect of COVID-19 pandemic confinement on AQI (μ1 = μ2). HA: Significant difference between the means of two groups i.e., air quality is significantly improved during COVID-19 pandemic confinement (μ1 > μ2), where μ1 and μ2 are the population means of the two groups.