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PMC:7546716 / 7442-9661 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T109 2-6 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T110 32-34 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T111 66-71 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T112 129-133 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T113 129-131 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T114 148-163 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T115 158-163 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T116 206-208 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T117 299-304 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T118 336-338 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T119 342-344 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T120 405-410 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T121 488-493 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T122 515-517 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T123 692-697 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T124 796-807 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T125 838-840 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T126 856-860 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T127 856-858 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T128 865-867 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T129 882-897 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T130 892-897 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T131 925-929 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T132 999-1002 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T133 1013-1027 Body_part denotes T helper cells http://purl.org/sig/ont/fma/fma70572
T134 1022-1027 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T135 1183-1188 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T136 1206-1215 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T137 1216-1227 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T138 1243-1247 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T139 1243-1245 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T140 1250-1252 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T141 1261-1263 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T142 1267-1271 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T143 1267-1269 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T144 1274-1276 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T145 1281-1283 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T146 1291-1293 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T147 1361-1366 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T148 1393-1398 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T149 1436-1441 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T150 1452-1454 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T151 1465-1468 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T152 1482-1485 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T153 1537-1546 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T154 1547-1558 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T155 1574-1583 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T156 1608-1617 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T157 1643-1652 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T158 1672-1681 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T159 1710-1717 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T160 1748-1751 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T161 1752-1763 Body_part denotes granulocyte http://purl.org/sig/ont/fma/fma62854
T162 1764-1774 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T163 1802-1804 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T164 1805-1816 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T165 1846-1850 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T166 1899-1906 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T167 1982-1989 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T168 2201-2218 Body_part denotes regulatory T cell http://purl.org/sig/ont/fma/fma84070
T169 2214-2218 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T61 23-31 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T62 828-836 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T63 1560-1567 Disease denotes CCR=C-C http://purl.obolibrary.org/obo/MONDO_0007763

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T96 0-6 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T97 52-57 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T98 66-71 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T99 98-103 http://purl.obolibrary.org/obo/CLO_0053477 denotes GATA3
T100 104-109 http://purl.obolibrary.org/obo/PR_000001350 denotes Foxp3
T101 111-116 http://purl.obolibrary.org/obo/CL_0000792 denotes Tregs
T102 129-133 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T103 148-163 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T104 199-204 http://purl.obolibrary.org/obo/CL_0000792 denotes Tregs
T105 275-278 http://purl.obolibrary.org/obo/CLO_0051025 denotes ST2
T106 299-304 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T107 403-410 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T108 488-493 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T109 545-570 http://purl.obolibrary.org/obo/PR_000001944 denotes transcription factor PU.1
T110 690-697 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T111 856-860 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T112 882-897 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T113 923-929 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T114 1013-1027 http://purl.obolibrary.org/obo/CL_0000912 denotes T helper cells
T115 1069-1079 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T116 1105-1106 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T117 1119-1129 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T118 1169-1174 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T119 1183-1188 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T120 1206-1215 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T121 1359-1366 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T122 1393-1398 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T123 1423-1426 http://purl.obolibrary.org/obo/CLO_0050389 denotes T17
T124 1436-1441 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T125 1512-1520 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T126 1537-1546 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T127 1633-1636 http://purl.obolibrary.org/obo/CLO_0009645 denotes X-C
T128 1633-1636 http://purl.obolibrary.org/obo/CLO_0050824 denotes X-C
T129 1668-1671 http://purl.obolibrary.org/obo/CLO_0009645 denotes X-C
T130 1668-1671 http://purl.obolibrary.org/obo/CLO_0050824 denotes X-C
T131 1830-1850 http://purl.obolibrary.org/obo/CL_0001065 denotes innate lymphoid cell
T132 1912-1913 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T133 1935-1936 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T134 1996-2021 http://purl.obolibrary.org/obo/PR_000001944 denotes transcription factor PU.1
T135 2056-2059 http://purl.obolibrary.org/obo/CLO_0051025 denotes ST2
T136 2060-2063 http://purl.obolibrary.org/obo/CLO_0051025 denotes ST2
T137 2079-2085 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T138 2115-2124 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T139 2196-2200 http://purl.obolibrary.org/obo/CL_0000792 denotes Treg
T140 2201-2218 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T81 32-34 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T83 129-131 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T85 206-208 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T87 336-338 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T89 342-344 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T91 379-387 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T92 497-502 Chemical denotes CXCL9 http://purl.obolibrary.org/obo/CHEBI_138154
T93 507-513 Chemical denotes CXCL10 http://purl.obolibrary.org/obo/CHEBI_138157
T94 515-517 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T96 776-781 Chemical denotes CXCL9 http://purl.obolibrary.org/obo/CHEBI_138154
T97 786-792 Chemical denotes CXCL10 http://purl.obolibrary.org/obo/CHEBI_138157
T98 838-840 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T100 856-858 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T102 865-867 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T104 996-998 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T105 1101-1103 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T108 1243-1245 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T110 1250-1252 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T112 1261-1263 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T114 1267-1269 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T116 1274-1276 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T118 1281-1283 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T120 1291-1293 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T122 1452-1454 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T124 1462-1464 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T125 1479-1481 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T126 1594-1597 Chemical denotes CCL http://purl.obolibrary.org/obo/CHEBI_3478
T127 1618-1624 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T128 1653-1659 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T129 1710-1717 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T130 1745-1747 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T131 1802-1804 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T133 1899-1906 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T134 1908-1910 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T137 1982-1989 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 2049-2054 Chemical denotes gamma http://purl.obolibrary.org/obo/CHEBI_30212
T139 2158-2160 Chemical denotes Th http://purl.obolibrary.org/obo/CHEBI_33385

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T16 129-144 http://purl.obolibrary.org/obo/GO_0032623 denotes IL-2 production
T17 388-394 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T18 545-565 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T19 545-558 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T20 925-939 http://purl.obolibrary.org/obo/GO_0016049 denotes cell expansion
T21 1996-2016 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T22 1996-2009 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T23 2101-2114 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T24 2143-2149 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T25 32-205 Sentence denotes IL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs.
T26 206-341 Sentence denotes IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9.
T27 342-514 Sentence denotes IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10.
T28 515-698 Sentence denotes IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells.
T29 699-808 Sentence denotes Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages.
T30 809-1028 Sentence denotes In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells.
T31 1029-1266 Sentence denotes At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6.
T32 1267-1469 Sentence denotes IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF.
T33 1470-1559 Sentence denotes In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages.
T34 1560-1593 Sentence denotes CCR=C-C motif chemokine receptor.
T35 1594-1625 Sentence denotes CCL=C-C motif chemokine ligand.
T36 1626-1660 Sentence denotes CXCL=C-X-C motif chemokine ligand.
T37 1661-1691 Sentence denotes CXCR=C-X-C chemokine receptor.
T38 1692-1718 Sentence denotes Foxp=forkhead box protein.
T39 1719-1744 Sentence denotes GATA=GATA-binding factor.
T40 1745-1801 Sentence denotes GM-CSF=granulocyte-macrophage colony-stimulating factor.
T41 1802-1817 Sentence denotes IL=interleukin.
T42 1818-1851 Sentence denotes ILC2=type 2 innate lymphoid cell.
T43 1852-1907 Sentence denotes MyD88=myeloid differentiation primary response protein.
T44 1908-1937 Sentence denotes NF-κB=nuclear factor-kappa B.
T45 1938-1990 Sentence denotes NLRP=NACHT, LRR, and PYD domains-containing protein.
T46 1991-2022 Sentence denotes PU.1=transcription factor PU.1.
T47 2023-2055 Sentence denotes RORC=nuclear receptor ROR-gamma.
T48 2056-2073 Sentence denotes ST2=ST2 receptor.
T49 2074-2125 Sentence denotes STAT=signal transducer and transcription activator.
T50 2126-2157 Sentence denotes TGF=transforming growth factor.
T51 2158-2170 Sentence denotes Th=T-helper.
T52 2171-2195 Sentence denotes TLR=toll-like receptors.
T53 2196-2219 Sentence denotes Treg=regulatory T cell.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
241 23-31 Disease denotes COVID-19 MESH:C000657245
293 32-37 Gene denotes IL-33 Gene:90865
294 98-103 Gene denotes GATA3 Gene:2625
295 104-109 Gene denotes Foxp3 Gene:50943
296 129-133 Gene denotes IL-2 Gene:3558
297 206-211 Gene denotes IL-33 Gene:90865
298 260-264 Gene denotes TGFβ Gene:7039
299 275-278 Gene denotes ST2 Gene:6761
300 336-340 Gene denotes IL-9 Gene:3578
301 342-346 Gene denotes IL-9 Gene:3578
302 457-462 Gene denotes CXCR3 Gene:2833
303 497-502 Gene denotes CXCL9 Gene:4283
304 507-513 Gene denotes CXCL10 Gene:3627
305 515-519 Gene denotes IL-9 Gene:3578
306 566-570 Gene denotes PU.1 Gene:6688
307 633-637 Gene denotes TGFβ Gene:7039
308 741-745 Gene denotes IFNγ Gene:3458
309 776-781 Gene denotes CXCL9 Gene:4283
310 786-792 Gene denotes CXCL10 Gene:3627
311 838-843 Gene denotes IL-33 Gene:90865
312 856-860 Gene denotes IL-2 Gene:3558
313 865-869 Gene denotes IL-7 Gene:3574
314 948-953 Gene denotes STAT5 Gene:6776
315 996-1002 Gene denotes GM-CSF Gene:1437
316 1087-1092 Gene denotes MyD88 Gene:4615
317 1101-1106 Gene denotes NF-κB Gene:4790
318 1137-1142 Gene denotes NLRP3 Gene:114548
319 1243-1248 Gene denotes IL-1β Gene:3552
320 1250-1255 Gene denotes IL-23 Gene:51561
321 1261-1265 Gene denotes IL-6 Gene:3569
322 1267-1272 Gene denotes IL-1β Gene:3552
323 1274-1279 Gene denotes IL-23 Gene:51561
324 1281-1285 Gene denotes IL-6 Gene:3569
325 1291-1295 Gene denotes IL-7 Gene:3574
326 1303-1308 Gene denotes STAT3 Gene:6774
327 1353-1357 Gene denotes CCR2 Gene:729230
328 1402-1406 Gene denotes CCL2 Gene:6347
329 1411-1415 Gene denotes CCL8 Gene:6355
330 1452-1457 Gene denotes IL-17 Gene:3605
331 1462-1468 Gene denotes GM-CSF Gene:1437
332 1479-1485 Gene denotes GM-CSF Gene:1437
333 1719-1743 Gene denotes GATA=GATA-binding factor Gene:55278
334 1852-1857 Gene denotes MyD88 Gene:4615
335 2017-2021 Gene denotes PU.1 Gene:6688
336 1943-1948 Gene denotes NACHT Gene:114548
337 1914-1936 Gene denotes nuclear factor-kappa B Gene:4790
338 1908-1913 Gene denotes NF-κB Gene:4790
339 1950-1953 Gene denotes LRR Gene:114548
340 1991-1995 Gene denotes PU.1 Gene:6688
341 199-204 Chemical denotes Tregs
342 1631-1636 Chemical denotes C-X-C
343 828-836 Disease denotes COVID-19 MESH:C000657245