Anti-IFNγ (eg, emapalumab) IFNγ Macrophages, dendritic cells, B cells, T cells, endothelial cells Might inhibit macrophage hyperactivation and induction of CXCL9 and CXCL10; might partly inhibit pathogenicity of effector T cells coexpressing GM-CSF and IFNγ Exogenous IFNγ inhibited the expression of GM-CSF by CD8+ T cells in haemophagocytic lymphohistiocytosis and MAS-like models with IFNγ deficiency; and anti-IFNγ might dampen protective antiviral cytotoxic T lymphocytes and B-cell responses orchestrated by interferons and Th1 cells