Additional important cell targets to focus on include ILC2, IL-17-producing and GM-CSF-producing γδT17 cells, proinflammatory monocytes–macrophages, extracellular trap-producing neutrophils, and mast cells. Different strategies could be set up to control aberrant activation of these cells, for instance by targeting IL-9 (MEDI-528), Vγ9Vδ2 T-cell activation (pentoxifylline),74 IL-17A, IL-17F, and IL-17E (bimekizumab, brodalumab),92 and cytokine balance (using colchicine,93 NLRP3 inhibitors,94 TLR2 inhibitors,95 JAK2 inhibitors,96 apremilast,97 mast cells stabilisers,55 and vitamin D).98