PMC:7546716 / 17734-20855 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7546716","sourcedb":"PMC","sourceid":"7546716","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7546716","text":"Suppression of antiviral responses and hyperinflammation\nAdvanced stages of COVID-19 are characterised by high circulating and pulmonary concentrations of IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1RA).6, 15, 25 The increased production of these molecules probably relates to high viral loads resulting in increased viroporins and subsequent activation of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome. The strong expression of IL-1α, IL-1β, and IL-1RA is also due to monocyte activation and intense lung infiltration of monocyte-derived macrophages at later stages, as suggested by an abundance of CD14+IL-1β+ monocytes in the circulation of patients with COVID-19 in the early stages of recovery.46 Active IL-1β is produced following NLRP3 assembly and consequent caspase-1 activation. By modulating ion fluxes across host cell membranes, viroporins (in particular the ORF3a protein) have been shown to activate NLRP3 during SARS-CoV infection, and a similar mechanism might be at play during SARS-CoV-2 infection.47\nAn imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-stranded RNA viruses that are predicted to bind directly to endosomal TLR7 and TLR8, and indirectly to TLR3 (using double-stranded RNA replication intermediates), aberrant inflammation induced by coronaviruses might instead involve membrane-expressed TLR2, as suggested by virus spike protein interactions with heparan sulphate-enriched regions of TLR2 in studies of the mouse hepatitis coronavirus.50 A predominance of MyD88 signalling over TRIF signalling would lead virus-exposed cells to produce high amounts of IL-1β, and NF-κB-induced cytokines and chemokines (eg, TNF, IL-8, IL-6, IL-12p40, IL-23, CCL2) rather than interferons, IL-12p35 and IL-12p70.30, 49, 50\nHigh concentrations of MyD88-related cytokines and reduced expression of TRIF-related cytokines characterise the cytokine milieu observed in the lungs of patients with severe and life-threatening COVID-19.15, 27, 28 Such an altered cytokine environment would polarise the immune response towards detrimental (Th17-sustained and GM-CSF-induced) hyperinflammation40, 41 caused by monocyte-derived macrophages and neutrophils, in place of protective (Th1-sustained and IFN-induced) antiviral responses exerted by cytotoxic T lymphocytes, natural killer cells, and B cells.29, 30 Altogether, coronaviruses seem to deceive and escape the immune system by eliciting a response that is generally more appropriate for extracellular rather than intracellular pathogens.","divisions":[{"label":"title","span":{"begin":0,"end":56}},{"label":"p","span":{"begin":57,"end":1051}},{"label":"p","span":{"begin":1052,"end":2360}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T325","span":{"begin":155,"end":159},"obj":"Body_part"},{"id":"T326","span":{"begin":155,"end":157},"obj":"Body_part"},{"id":"T327","span":{"begin":162,"end":166},"obj":"Body_part"},{"id":"T328","span":{"begin":162,"end":164},"obj":"Body_part"},{"id":"T329","span":{"begin":173,"end":177},"obj":"Body_part"},{"id":"T330","span":{"begin":173,"end":175},"obj":"Body_part"},{"id":"T331","span":{"begin":199,"end":201},"obj":"Body_part"},{"id":"T332","span":{"begin":404,"end":411},"obj":"Body_part"},{"id":"T333","span":{"begin":461,"end":465},"obj":"Body_part"},{"id":"T334","span":{"begin":461,"end":463},"obj":"Body_part"},{"id":"T335","span":{"begin":468,"end":472},"obj":"Body_part"},{"id":"T336","span":{"begin":468,"end":470},"obj":"Body_part"},{"id":"T337","span":{"begin":479,"end":481},"obj":"Body_part"},{"id":"T338","span":{"begin":501,"end":509},"obj":"Body_part"},{"id":"T339","span":{"begin":533,"end":537},"obj":"Body_part"},{"id":"T340","span":{"begin":554,"end":562},"obj":"Body_part"},{"id":"T341","span":{"begin":571,"end":582},"obj":"Body_part"},{"id":"T342","span":{"begin":637,"end":641},"obj":"Body_part"},{"id":"T343","span":{"begin":637,"end":639},"obj":"Body_part"},{"id":"T344","span":{"begin":644,"end":653},"obj":"Body_part"},{"id":"T345","span":{"begin":741,"end":745},"obj":"Body_part"},{"id":"T346","span":{"begin":741,"end":743},"obj":"Body_part"},{"id":"T347","span":{"begin":858,"end":872},"obj":"Body_part"},{"id":"T348","span":{"begin":858,"end":862},"obj":"Body_part"},{"id":"T349","span":{"begin":910,"end":917},"obj":"Body_part"},{"id":"T350","span":{"begin":1169,"end":1176},"obj":"Body_part"},{"id":"T351","span":{"begin":1365,"end":1369},"obj":"Body_part"},{"id":"T352","span":{"begin":1365,"end":1367},"obj":"Body_part"},{"id":"T353","span":{"begin":1402,"end":1404},"obj":"Body_part"},{"id":"T354","span":{"begin":1544,"end":1553},"obj":"Body_part"},{"id":"T355","span":{"begin":1701,"end":1704},"obj":"Body_part"},{"id":"T356","span":{"begin":1752,"end":1761},"obj":"Body_part"},{"id":"T357","span":{"begin":1823,"end":1826},"obj":"Body_part"},{"id":"T358","span":{"begin":1977,"end":1984},"obj":"Body_part"},{"id":"T359","span":{"begin":2003,"end":2010},"obj":"Body_part"},{"id":"T360","span":{"begin":2175,"end":2180},"obj":"Body_part"},{"id":"T361","span":{"begin":2208,"end":2212},"obj":"Body_part"},{"id":"T362","span":{"begin":2208,"end":2210},"obj":"Body_part"},{"id":"T363","span":{"begin":2233,"end":2242},"obj":"Body_part"},{"id":"T364","span":{"begin":2247,"end":2257},"obj":"Body_part"},{"id":"T365","span":{"begin":2268,"end":2270},"obj":"Body_part"},{"id":"T366","span":{"begin":2274,"end":2276},"obj":"Body_part"},{"id":"T367","span":{"begin":2280,"end":2282},"obj":"Body_part"},{"id":"T368","span":{"begin":2290,"end":2292},"obj":"Body_part"},{"id":"T369","span":{"begin":2328,"end":2330},"obj":"Body_part"},{"id":"T370","span":{"begin":2341,"end":2343},"obj":"Body_part"},{"id":"T371","span":{"begin":2398,"end":2407},"obj":"Body_part"},{"id":"T372","span":{"begin":2447,"end":2456},"obj":"Body_part"},{"id":"T373","span":{"begin":2474,"end":2482},"obj":"Body_part"},{"id":"T374","span":{"begin":2506,"end":2511},"obj":"Body_part"},{"id":"T375","span":{"begin":2593,"end":2601},"obj":"Body_part"},{"id":"T376","span":{"begin":2692,"end":2695},"obj":"Body_part"},{"id":"T377","span":{"begin":2739,"end":2747},"obj":"Body_part"},{"id":"T378","span":{"begin":2756,"end":2767},"obj":"Body_part"},{"id":"T379","span":{"begin":2772,"end":2783},"obj":"Body_part"},{"id":"T380","span":{"begin":2871,"end":2894},"obj":"Body_part"},{"id":"T381","span":{"begin":2896,"end":2916},"obj":"Body_part"},{"id":"T382","span":{"begin":2911,"end":2916},"obj":"Body_part"},{"id":"T383","span":{"begin":2924,"end":2929},"obj":"Body_part"},{"id":"T384","span":{"begin":2994,"end":3007},"obj":"Body_part"}],"attributes":[{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A327","pred":"fma_id","subj":"T327","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A328","pred":"fma_id","subj":"T328","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A329","pred":"fma_id","subj":"T329","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A330","pred":"fma_id","subj":"T330","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A331","pred":"fma_id","subj":"T331","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A332","pred":"fma_id","subj":"T332","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A333","pred":"fma_id","subj":"T333","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A334","pred":"fma_id","subj":"T334","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A335","pred":"fma_id","subj":"T335","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A336","pred":"fma_id","subj":"T336","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A337","pred":"fma_id","subj":"T337","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A338","pred":"fma_id","subj":"T338","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A339","pred":"fma_id","subj":"T339","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A340","pred":"fma_id","subj":"T340","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A341","pred":"fma_id","subj":"T341","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A342","pred":"fma_id","subj":"T342","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A343","pred":"fma_id","subj":"T343","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A344","pred":"fma_id","subj":"T344","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A345","pred":"fma_id","subj":"T345","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A346","pred":"fma_id","subj":"T346","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A347","pred":"fma_id","subj":"T347","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A348","pred":"fma_id","subj":"T348","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A349","pred":"fma_id","subj":"T349","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A350","pred":"fma_id","subj":"T350","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A351","pred":"fma_id","subj":"T351","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A352","pred":"fma_id","subj":"T352","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A353","pred":"fma_id","subj":"T353","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A354","pred":"fma_id","subj":"T354","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A355","pred":"fma_id","subj":"T355","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A356","pred":"fma_id","subj":"T356","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A357","pred":"fma_id","subj":"T357","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A358","pred":"fma_id","subj":"T358","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A359","pred":"fma_id","subj":"T359","obj":"http://purl.org/sig/ont/fma/fma67110"},{"id":"A360","pred":"fma_id","subj":"T360","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A361","pred":"fma_id","subj":"T361","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A362","pred":"fma_id","subj":"T362","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A363","pred":"fma_id","subj":"T363","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A364","pred":"fma_id","subj":"T364","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A371","pred":"fma_id","subj":"T371","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A372","pred":"fma_id","subj":"T372","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A373","pred":"fma_id","subj":"T373","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A374","pred":"fma_id","subj":"T374","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A375","pred":"fma_id","subj":"T375","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A376","pred":"fma_id","subj":"T376","obj":"http://purl.org/sig/ont/fma/fma20935"},{"id":"A377","pred":"fma_id","subj":"T377","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A378","pred":"fma_id","subj":"T378","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A379","pred":"fma_id","subj":"T379","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A380","pred":"fma_id","subj":"T380","obj":"http://purl.org/sig/ont/fma/fma70573"},{"id":"A381","pred":"fma_id","subj":"T381","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A382","pred":"fma_id","subj":"T382","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A383","pred":"fma_id","subj":"T383","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A384","pred":"fma_id","subj":"T384","obj":"http://purl.org/sig/ont/fma/fma9825"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T337","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T338","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T339","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T340","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T341","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T342","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T343","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T344","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T345","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T346","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T347","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T348","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T349","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T350","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T351","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T352","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T353","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T354","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T355","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T356","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T357","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T358","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T359","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T360","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T361","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T362","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T363","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T364","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T365","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T366","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T367","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T368","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T369","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T370","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T371","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T372","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T373","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T374","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T375","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T376","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T377","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T378","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T379","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T380","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T381","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T382","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T383","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T384","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T19","span":{"begin":533,"end":537},"obj":"Body_part"},{"id":"T20","span":{"begin":2994,"end":3007},"obj":"Body_part"}],"attributes":[{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T105","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T106","span":{"begin":690,"end":698},"obj":"Disease"},{"id":"T107","span":{"begin":960,"end":978},"obj":"Disease"},{"id":"T108","span":{"begin":969,"end":978},"obj":"Disease"},{"id":"T109","span":{"begin":1028,"end":1036},"obj":"Disease"},{"id":"T110","span":{"begin":1039,"end":1048},"obj":"Disease"},{"id":"T111","span":{"begin":1485,"end":1497},"obj":"Disease"},{"id":"T112","span":{"begin":1864,"end":1876},"obj":"Disease"},{"id":"T113","span":{"begin":2069,"end":2078},"obj":"Disease"}],"attributes":[{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T257","span":{"begin":347,"end":357},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T258","span":{"begin":501,"end":509},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T259","span":{"begin":510,"end":520},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T260","span":{"begin":533,"end":537},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T261","span":{"begin":533,"end":537},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T262","span":{"begin":554,"end":562},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T263","span":{"begin":644,"end":653},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T264","span":{"begin":734,"end":740},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T265","span":{"begin":809,"end":819},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T266","span":{"begin":858,"end":862},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T267","span":{"begin":863,"end":872},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T268","span":{"begin":938,"end":946},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T269","span":{"begin":984,"end":985},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T270","span":{"begin":1068,"end":1078},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T271","span":{"begin":1326,"end":1336},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T272","span":{"begin":1337,"end":1339},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T273","span":{"begin":1340,"end":1350},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T274","span":{"begin":1417,"end":1420},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T275","span":{"begin":1440,"end":1448},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T276","span":{"begin":1459,"end":1467},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T277","span":{"begin":1651,"end":1653},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T278","span":{"begin":1705,"end":1712},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T279","span":{"begin":1924,"end":1932},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T280","span":{"begin":1943,"end":1947},"obj":"http://purl.obolibrary.org/obo/CLO_0050768"},{"id":"T281","span":{"begin":1965,"end":1970},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T282","span":{"begin":2040,"end":2044},"obj":"http://purl.obolibrary.org/obo/CLO_0050768"},{"id":"T283","span":{"begin":2063,"end":2068},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T284","span":{"begin":2094,"end":2095},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T285","span":{"begin":2118,"end":2128},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T286","span":{"begin":2139,"end":2149},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T287","span":{"begin":2161,"end":2166},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T288","span":{"begin":2175,"end":2180},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T289","span":{"begin":2223,"end":2224},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T290","span":{"begin":2268,"end":2272},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T291","span":{"begin":2506,"end":2511},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T292","span":{"begin":2570,"end":2572},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T293","span":{"begin":2726,"end":2728},"obj":"http://purl.obolibrary.org/obo/CLO_0053794"},{"id":"T294","span":{"begin":2739,"end":2747},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T295","span":{"begin":2896,"end":2916},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T296","span":{"begin":2922,"end":2929},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T297","span":{"begin":2994,"end":3007},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T298","span":{"begin":3021,"end":3022},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T257","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T273","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T281","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T282","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T285","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T289","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T290","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T291","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T292","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T293","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T294","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T297","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T298","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T246","span":{"begin":15,"end":24},"obj":"Chemical"},{"id":"T247","span":{"begin":155,"end":157},"obj":"Chemical"},{"id":"T249","span":{"begin":162,"end":164},"obj":"Chemical"},{"id":"T251","span":{"begin":173,"end":175},"obj":"Chemical"},{"id":"T253","span":{"begin":187,"end":197},"obj":"Chemical"},{"id":"T254","span":{"begin":199,"end":201},"obj":"Chemical"},{"id":"T256","span":{"begin":251,"end":260},"obj":"Chemical"},{"id":"T257","span":{"begin":404,"end":411},"obj":"Chemical"},{"id":"T258","span":{"begin":461,"end":463},"obj":"Chemical"},{"id":"T260","span":{"begin":468,"end":470},"obj":"Chemical"},{"id":"T262","span":{"begin":479,"end":481},"obj":"Chemical"},{"id":"T264","span":{"begin":637,"end":639},"obj":"Chemical"},{"id":"T266","span":{"begin":741,"end":743},"obj":"Chemical"},{"id":"T268","span":{"begin":835,"end":838},"obj":"Chemical"},{"id":"T269","span":{"begin":910,"end":917},"obj":"Chemical"},{"id":"T270","span":{"begin":1169,"end":1176},"obj":"Chemical"},{"id":"T271","span":{"begin":1246,"end":1254},"obj":"Chemical"},{"id":"T272","span":{"begin":1365,"end":1367},"obj":"Chemical"},{"id":"T274","span":{"begin":1402,"end":1404},"obj":"Chemical"},{"id":"T276","span":{"begin":1586,"end":1595},"obj":"Chemical"},{"id":"T277","span":{"begin":1596,"end":1606},"obj":"Chemical"},{"id":"T278","span":{"begin":1807,"end":1826},"obj":"Chemical"},{"id":"T279","span":{"begin":1977,"end":1984},"obj":"Chemical"},{"id":"T280","span":{"begin":2003,"end":2010},"obj":"Chemical"},{"id":"T281","span":{"begin":2011,"end":2019},"obj":"Chemical"},{"id":"T282","span":{"begin":2208,"end":2210},"obj":"Chemical"},{"id":"T284","span":{"begin":2219,"end":2221},"obj":"Chemical"},{"id":"T287","span":{"begin":2268,"end":2270},"obj":"Chemical"},{"id":"T289","span":{"begin":2274,"end":2276},"obj":"Chemical"},{"id":"T291","span":{"begin":2280,"end":2282},"obj":"Chemical"},{"id":"T293","span":{"begin":2290,"end":2292},"obj":"Chemical"},{"id":"T295","span":{"begin":2328,"end":2330},"obj":"Chemical"},{"id":"T297","span":{"begin":2341,"end":2343},"obj":"Chemical"},{"id":"T299","span":{"begin":2689,"end":2691},"obj":"Chemical"},{"id":"T300","span":{"begin":2840,"end":2849},"obj":"Chemical"}],"attributes":[{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A247","pred":"chebi_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A248","pred":"chebi_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A250","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A252","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A255","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A259","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A261","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A262","pred":"chebi_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A263","pred":"chebi_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A265","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A266","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A267","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A268","pred":"chebi_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A269","pred":"chebi_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A270","pred":"chebi_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A271","pred":"chebi_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A272","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A273","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A274","pred":"chebi_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A275","pred":"chebi_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A276","pred":"chebi_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A277","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A278","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_67208"},{"id":"A279","pred":"chebi_id","subj":"T279","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A280","pred":"chebi_id","subj":"T280","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A281","pred":"chebi_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A282","pred":"chebi_id","subj":"T282","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A283","pred":"chebi_id","subj":"T282","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A284","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A285","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A286","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A287","pred":"chebi_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A288","pred":"chebi_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A289","pred":"chebi_id","subj":"T289","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A290","pred":"chebi_id","subj":"T289","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A291","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A292","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A293","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A294","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A295","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A296","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A297","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A298","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A300","pred":"chebi_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T281","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T282","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T289","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T291","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T293","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T297","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T299","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T300","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T20","span":{"begin":533,"end":550},"obj":"Phenotype"},{"id":"T21","span":{"begin":2069,"end":2078},"obj":"Phenotype"}],"attributes":[{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0002113"},{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0012115"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T43","span":{"begin":15,"end":34},"obj":"http://purl.obolibrary.org/obo/GO_0051607"},{"id":"T44","span":{"begin":199,"end":205},"obj":"http://purl.obolibrary.org/obo/GO_0005152"},{"id":"T45","span":{"begin":321,"end":331},"obj":"http://purl.obolibrary.org/obo/GO_0039707"},{"id":"T46","span":{"begin":479,"end":485},"obj":"http://purl.obolibrary.org/obo/GO_0005152"},{"id":"T47","span":{"begin":501,"end":520},"obj":"http://purl.obolibrary.org/obo/GO_0042117"},{"id":"T48","span":{"begin":874,"end":884},"obj":"http://purl.obolibrary.org/obo/GO_0039707"},{"id":"T49","span":{"begin":1068,"end":1078},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T50","span":{"begin":1340,"end":1350},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T51","span":{"begin":1485,"end":1497},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T52","span":{"begin":1823,"end":1838},"obj":"http://purl.obolibrary.org/obo/GO_0039703"},{"id":"T53","span":{"begin":1864,"end":1876},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T54","span":{"begin":2118,"end":2128},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T55","span":{"begin":2139,"end":2149},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T56","span":{"begin":2633,"end":2648},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T57","span":{"begin":2840,"end":2859},"obj":"http://purl.obolibrary.org/obo/GO_0051607"}],"attributes":[{"subj":"T43","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T75","span":{"begin":0,"end":56},"obj":"Sentence"},{"id":"T76","span":{"begin":57,"end":435},"obj":"Sentence"},{"id":"T77","span":{"begin":436,"end":820},"obj":"Sentence"},{"id":"T78","span":{"begin":821,"end":1051},"obj":"Sentence"},{"id":"T79","span":{"begin":1052,"end":2360},"obj":"Sentence"},{"id":"T80","span":{"begin":2361,"end":3121},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T75","pred":"source","obj":"LitCovid-sentences"},{"subj":"T76","pred":"source","obj":"LitCovid-sentences"},{"subj":"T77","pred":"source","obj":"LitCovid-sentences"},{"subj":"T78","pred":"source","obj":"LitCovid-sentences"},{"subj":"T79","pred":"source","obj":"LitCovid-sentences"},{"subj":"T80","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"753","span":{"begin":155,"end":160},"obj":"Gene"},{"id":"754","span":{"begin":162,"end":167},"obj":"Gene"},{"id":"755","span":{"begin":173,"end":197},"obj":"Gene"},{"id":"756","span":{"begin":199,"end":205},"obj":"Gene"},{"id":"757","span":{"begin":365,"end":413},"obj":"Gene"},{"id":"758","span":{"begin":415,"end":420},"obj":"Gene"},{"id":"759","span":{"begin":461,"end":466},"obj":"Gene"},{"id":"760","span":{"begin":468,"end":473},"obj":"Gene"},{"id":"761","span":{"begin":479,"end":485},"obj":"Gene"},{"id":"762","span":{"begin":637,"end":642},"obj":"Gene"},{"id":"763","span":{"begin":741,"end":746},"obj":"Gene"},{"id":"764","span":{"begin":769,"end":774},"obj":"Gene"},{"id":"765","span":{"begin":799,"end":808},"obj":"Gene"},{"id":"766","span":{"begin":947,"end":952},"obj":"Gene"},{"id":"767","span":{"begin":676,"end":684},"obj":"Species"},{"id":"768","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"769","span":{"begin":690,"end":698},"obj":"Disease"},{"id":"770","span":{"begin":960,"end":978},"obj":"Disease"},{"id":"771","span":{"begin":1028,"end":1048},"obj":"Disease"},{"id":"800","span":{"begin":1178,"end":1183},"obj":"Gene"},{"id":"801","span":{"begin":1216,"end":1256},"obj":"Gene"},{"id":"802","span":{"begin":1258,"end":1265},"obj":"Gene"},{"id":"803","span":{"begin":1281,"end":1285},"obj":"Gene"},{"id":"804","span":{"begin":1320,"end":1325},"obj":"Gene"},{"id":"805","span":{"begin":1365,"end":1369},"obj":"Gene"},{"id":"806","span":{"begin":1468,"end":1473},"obj":"Gene"},{"id":"807","span":{"begin":1507,"end":1511},"obj":"Gene"},{"id":"808","span":{"begin":1943,"end":1947},"obj":"Gene"},{"id":"809","span":{"begin":2040,"end":2044},"obj":"Gene"},{"id":"810","span":{"begin":2112,"end":2117},"obj":"Gene"},{"id":"811","span":{"begin":2134,"end":2138},"obj":"Gene"},{"id":"812","span":{"begin":2208,"end":2213},"obj":"Gene"},{"id":"813","span":{"begin":2219,"end":2224},"obj":"Gene"},{"id":"814","span":{"begin":2263,"end":2266},"obj":"Gene"},{"id":"815","span":{"begin":2268,"end":2272},"obj":"Gene"},{"id":"816","span":{"begin":2274,"end":2278},"obj":"Gene"},{"id":"817","span":{"begin":2290,"end":2295},"obj":"Gene"},{"id":"818","span":{"begin":2297,"end":2301},"obj":"Gene"},{"id":"819","span":{"begin":1637,"end":1650},"obj":"Species"},{"id":"820","span":{"begin":1667,"end":1680},"obj":"Species"},{"id":"821","span":{"begin":1888,"end":1901},"obj":"Species"},{"id":"822","span":{"begin":2063,"end":2068},"obj":"Species"},{"id":"823","span":{"begin":2003,"end":2019},"obj":"Chemical"},{"id":"824","span":{"begin":1485,"end":1497},"obj":"Disease"},{"id":"825","span":{"begin":1544,"end":1558},"obj":"Disease"},{"id":"826","span":{"begin":1864,"end":1876},"obj":"Disease"},{"id":"827","span":{"begin":2069,"end":2090},"obj":"Disease"},{"id":"835","span":{"begin":2384,"end":2389},"obj":"Gene"},{"id":"836","span":{"begin":2434,"end":2438},"obj":"Gene"},{"id":"837","span":{"begin":2689,"end":2695},"obj":"Gene"},{"id":"838","span":{"begin":2515,"end":2523},"obj":"Species"},{"id":"839","span":{"begin":2949,"end":2962},"obj":"Species"},{"id":"840","span":{"begin":2809,"end":2812},"obj":"Chemical"},{"id":"841","span":{"begin":2557,"end":2565},"obj":"Disease"}],"attributes":[{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"Gene:3552"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"Gene:3552"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"Gene:3557"},{"id":"A756","pred":"tao:has_database_id","subj":"756","obj":"Gene:3557"},{"id":"A757","pred":"tao:has_database_id","subj":"757","obj":"Gene:114548"},{"id":"A758","pred":"tao:has_database_id","subj":"758","obj":"Gene:114548"},{"id":"A759","pred":"tao:has_database_id","subj":"759","obj":"Gene:3552"},{"id":"A760","pred":"tao:has_database_id","subj":"760","obj":"Gene:3552"},{"id":"A761","pred":"tao:has_database_id","subj":"761","obj":"Gene:3557"},{"id":"A762","pred":"tao:has_database_id","subj":"762","obj":"Gene:3552"},{"id":"A763","pred":"tao:has_database_id","subj":"763","obj":"Gene:3552"},{"id":"A764","pred":"tao:has_database_id","subj":"764","obj":"Gene:114548"},{"id":"A765","pred":"tao:has_database_id","subj":"765","obj":"Gene:834"},{"id":"A766","pred":"tao:has_database_id","subj":"766","obj":"Gene:114548"},{"id":"A767","pred":"tao:has_database_id","subj":"767","obj":"Tax:9606"},{"id":"A768","pred":"tao:has_database_id","subj":"768","obj":"MESH:C000657245"},{"id":"A769","pred":"tao:has_database_id","subj":"769","obj":"MESH:C000657245"},{"id":"A770","pred":"tao:has_database_id","subj":"770","obj":"MESH:C000657245"},{"id":"A771","pred":"tao:has_database_id","subj":"771","obj":"MESH:C000657245"},{"id":"A800","pred":"tao:has_database_id","subj":"800","obj":"Gene:4615"},{"id":"A801","pred":"tao:has_database_id","subj":"801","obj":"Gene:148022"},{"id":"A802","pred":"tao:has_database_id","subj":"802","obj":"Gene:148022"},{"id":"A803","pred":"tao:has_database_id","subj":"803","obj":"Gene:148022"},{"id":"A804","pred":"tao:has_database_id","subj":"804","obj":"Gene:114548"},{"id":"A805","pred":"tao:has_database_id","subj":"805","obj":"Gene:3552"},{"id":"A806","pred":"tao:has_database_id","subj":"806","obj":"Gene:4615"},{"id":"A807","pred":"tao:has_database_id","subj":"807","obj":"Gene:148022"},{"id":"A808","pred":"tao:has_database_id","subj":"808","obj":"Gene:7097"},{"id":"A809","pred":"tao:has_database_id","subj":"809","obj":"Gene:7097"},{"id":"A810","pred":"tao:has_database_id","subj":"810","obj":"Gene:4615"},{"id":"A811","pred":"tao:has_database_id","subj":"811","obj":"Gene:148022"},{"id":"A812","pred":"tao:has_database_id","subj":"812","obj":"Gene:3552"},{"id":"A813","pred":"tao:has_database_id","subj":"813","obj":"Gene:4790"},{"id":"A814","pred":"tao:has_database_id","subj":"814","obj":"Gene:7124"},{"id":"A815","pred":"tao:has_database_id","subj":"815","obj":"Gene:3576"},{"id":"A816","pred":"tao:has_database_id","subj":"816","obj":"Gene:3569"},{"id":"A817","pred":"tao:has_database_id","subj":"817","obj":"Gene:51561"},{"id":"A818","pred":"tao:has_database_id","subj":"818","obj":"Gene:6347"},{"id":"A819","pred":"tao:has_database_id","subj":"819","obj":"Tax:11118"},{"id":"A820","pred":"tao:has_database_id","subj":"820","obj":"Tax:11118"},{"id":"A821","pred":"tao:has_database_id","subj":"821","obj":"Tax:11118"},{"id":"A822","pred":"tao:has_database_id","subj":"822","obj":"Tax:10090"},{"id":"A823","pred":"tao:has_database_id","subj":"823","obj":"MESH:D006497"},{"id":"A824","pred":"tao:has_database_id","subj":"824","obj":"MESH:D007249"},{"id":"A826","pred":"tao:has_database_id","subj":"826","obj":"MESH:D007249"},{"id":"A827","pred":"tao:has_database_id","subj":"827","obj":"MESH:D056486"},{"id":"A835","pred":"tao:has_database_id","subj":"835","obj":"Gene:4615"},{"id":"A836","pred":"tao:has_database_id","subj":"836","obj":"Gene:148022"},{"id":"A837","pred":"tao:has_database_id","subj":"837","obj":"Gene:1437"},{"id":"A838","pred":"tao:has_database_id","subj":"838","obj":"Tax:9606"},{"id":"A839","pred":"tao:has_database_id","subj":"839","obj":"Tax:11118"},{"id":"A841","pred":"tao:has_database_id","subj":"841","obj":"MESH:C000657245"},{"subj":"753","pred":"source","obj":"LitCovid-PubTator"},{"subj":"754","pred":"source","obj":"LitCovid-PubTator"},{"subj":"755","pred":"source","obj":"LitCovid-PubTator"},{"subj":"756","pred":"source","obj":"LitCovid-PubTator"},{"subj":"757","pred":"source","obj":"LitCovid-PubTator"},{"subj":"758","pred":"source","obj":"LitCovid-PubTator"},{"subj":"759","pred":"source","obj":"LitCovid-PubTator"},{"subj":"760","pred":"source","obj":"LitCovid-PubTator"},{"subj":"761","pred":"source","obj":"LitCovid-PubTator"},{"subj":"762","pred":"source","obj":"LitCovid-PubTator"},{"subj":"763","pred":"source","obj":"LitCovid-PubTator"},{"subj":"764","pred":"source","obj":"LitCovid-PubTator"},{"subj":"765","pred":"source","obj":"LitCovid-PubTator"},{"subj":"766","pred":"source","obj":"LitCovid-PubTator"},{"subj":"767","pred":"source","obj":"LitCovid-PubTator"},{"subj":"768","pred":"source","obj":"LitCovid-PubTator"},{"subj":"769","pred":"source","obj":"LitCovid-PubTator"},{"subj":"770","pred":"source","obj":"LitCovid-PubTator"},{"subj":"771","pred":"source","obj":"LitCovid-PubTator"},{"subj":"800","pred":"source","obj":"LitCovid-PubTator"},{"subj":"801","pred":"source","obj":"LitCovid-PubTator"},{"subj":"802","pred":"source","obj":"LitCovid-PubTator"},{"subj":"803","pred":"source","obj":"LitCovid-PubTator"},{"subj":"804","pred":"source","obj":"LitCovid-PubTator"},{"subj":"805","pred":"source","obj":"LitCovid-PubTator"},{"subj":"806","pred":"source","obj":"LitCovid-PubTator"},{"subj":"807","pred":"source","obj":"LitCovid-PubTator"},{"subj":"808","pred":"source","obj":"LitCovid-PubTator"},{"subj":"809","pred":"source","obj":"LitCovid-PubTator"},{"subj":"810","pred":"source","obj":"LitCovid-PubTator"},{"subj":"811","pred":"source","obj":"LitCovid-PubTator"},{"subj":"812","pred":"source","obj":"LitCovid-PubTator"},{"subj":"813","pred":"source","obj":"LitCovid-PubTator"},{"subj":"814","pred":"source","obj":"LitCovid-PubTator"},{"subj":"815","pred":"source","obj":"LitCovid-PubTator"},{"subj":"816","pred":"source","obj":"LitCovid-PubTator"},{"subj":"817","pred":"source","obj":"LitCovid-PubTator"},{"subj":"818","pred":"source","obj":"LitCovid-PubTator"},{"subj":"819","pred":"source","obj":"LitCovid-PubTator"},{"subj":"820","pred":"source","obj":"LitCovid-PubTator"},{"subj":"821","pred":"source","obj":"LitCovid-PubTator"},{"subj":"822","pred":"source","obj":"LitCovid-PubTator"},{"subj":"823","pred":"source","obj":"LitCovid-PubTator"},{"subj":"824","pred":"source","obj":"LitCovid-PubTator"},{"subj":"825","pred":"source","obj":"LitCovid-PubTator"},{"subj":"826","pred":"source","obj":"LitCovid-PubTator"},{"subj":"827","pred":"source","obj":"LitCovid-PubTator"},{"subj":"835","pred":"source","obj":"LitCovid-PubTator"},{"subj":"836","pred":"source","obj":"LitCovid-PubTator"},{"subj":"837","pred":"source","obj":"LitCovid-PubTator"},{"subj":"838","pred":"source","obj":"LitCovid-PubTator"},{"subj":"839","pred":"source","obj":"LitCovid-PubTator"},{"subj":"840","pred":"source","obj":"LitCovid-PubTator"},{"subj":"841","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"33073244-32398875-66244580","span":{"begin":210,"end":212},"obj":"32398875"},{"id":"33073244-32360286-66244581","span":{"begin":214,"end":216},"obj":"32360286"},{"id":"33073244-32377375-66244582","span":{"begin":731,"end":733},"obj":"32377375"},{"id":"33073244-26015500-66244583","span":{"begin":1655,"end":1657},"obj":"26015500"},{"id":"33073244-19740307-66244584","span":{"begin":2091,"end":2093},"obj":"19740307"},{"id":"33073244-32661059-66244585","span":{"begin":2350,"end":2352},"obj":"32661059"},{"id":"33073244-26015500-66244586","span":{"begin":2354,"end":2356},"obj":"26015500"},{"id":"33073244-19740307-66244587","span":{"begin":2358,"end":2360},"obj":"19740307"},{"id":"33073244-32398875-66244588","span":{"begin":2566,"end":2568},"obj":"32398875"},{"id":"33073244-32416070-66244589","span":{"begin":2570,"end":2572},"obj":"32416070"},{"id":"33073244-22345669-66244590","span":{"begin":2722,"end":2724},"obj":"22345669"},{"id":"33073244-21516111-66244591","span":{"begin":2726,"end":2728},"obj":"21516111"},{"id":"33073244-32505227-66244592","span":{"begin":2930,"end":2932},"obj":"32505227"},{"id":"33073244-32661059-66244593","span":{"begin":2934,"end":2936},"obj":"32661059"}],"attributes":[{"subj":"33073244-32398875-66244580","pred":"source","obj":"2_test"},{"subj":"33073244-32360286-66244581","pred":"source","obj":"2_test"},{"subj":"33073244-32377375-66244582","pred":"source","obj":"2_test"},{"subj":"33073244-26015500-66244583","pred":"source","obj":"2_test"},{"subj":"33073244-19740307-66244584","pred":"source","obj":"2_test"},{"subj":"33073244-32661059-66244585","pred":"source","obj":"2_test"},{"subj":"33073244-26015500-66244586","pred":"source","obj":"2_test"},{"subj":"33073244-19740307-66244587","pred":"source","obj":"2_test"},{"subj":"33073244-32398875-66244588","pred":"source","obj":"2_test"},{"subj":"33073244-32416070-66244589","pred":"source","obj":"2_test"},{"subj":"33073244-22345669-66244590","pred":"source","obj":"2_test"},{"subj":"33073244-21516111-66244591","pred":"source","obj":"2_test"},{"subj":"33073244-32505227-66244592","pred":"source","obj":"2_test"},{"subj":"33073244-32661059-66244593","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93aa","default":true},{"id":"LitCovid-PD-UBERON","color":"#93c4ec"},{"id":"LitCovid-PD-MONDO","color":"#deec93"},{"id":"LitCovid-PD-CLO","color":"#e093ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecc6"},{"id":"LitCovid-PD-HP","color":"#ecac93"},{"id":"LitCovid-PD-GO-BP","color":"#9393ec"},{"id":"LitCovid-sentences","color":"#adec93"},{"id":"LitCovid-PubTator","color":"#ec93c8"},{"id":"2_test","color":"#93e2ec"}]}]}}