In contrast, HCoV-229E nAb titers between 1:43 and 1:196 (mean = 1:98) were measured for the 54 IVIG lots tested (Figure 1B). IVIG lots produced from recovered plasma contained significantly higher levels of nAb to HCoV-229E as compared to IVIG lots produced from source plasma, independent of the geographic origin. A significant, although quantitatively minor, difference was also found between IVIG lots manufactured from source plasma collected in either the United States or Europe.