With increasing numbers of human infections, including in the plasma donor community, it is interesting to follow the development of antibodies against SARS-CoV-2 in plasma donations and, after the several months production cycle time between plasma donation and IVIG lot release, also in IVIG lots. A longitudinal study on this topic is currently in progress. In this context it is noteworthy that the mean nAb titers induced by WNV [1] and SARS-CoV-2 [9] infection are of similar magnitude. After the emergence of WNV in the United States, nAb titers became detectable in IVIGs after approximately 0.5% of the population had contracted and recovered from the infection. In Austria, testing of plasma pool samples indicated that up to 1.17% of plasma donors were positive for SARS-CoV-2 nAbs. Based on the current number of reported SARS-CoV-2 infections in the United States (approximately 4.3 million per 30 July 2020; www.cdc.gov), and an estimated rate of >40% asymptomatic infections [15], more than 7.2 million people in the United States could have been infected already, that is 2.2% of the approximately 330 million population. Based on these facts, the detection of SARS-CoV-2 nAbs in IVIG lots produced from US plasma, the major source for fractionation, is expected within the next few months.