In clear contrast, testing the same lots of IVIG that were shown to contain high HCoV-229E nAb titers with a highly specific SARS-CoV-2 µNT did not detect SARS-CoV-2–specific nAbs. These results are entirely consistent with the absence of SARS-CoV-2 antibodies in the plasma used for production of these IVIG lots, as this plasma was donated well before the start of the SARS-CoV-2 pandemic.