Our analysis of IVIG lots revealed high nAb titers to HCoV-229E (Figure 1B), which confirmed the presence of functionally intact nAbs in these lots. It is interesting to note that in IVIG lots produced from recovered plasma significantly higher titers to HCoV-229E were found compared to IVIG lots produced from source plasma, independent of plasma origin. Recovered plasma is usually obtained from older donors [11]. A trend towards increasing probability of HCoV-229E infections with age has been detected in the Scottish [3] and US [4] population. Furthermore, higher HCoV-229E–specific nAb titers were found in older study participants (60–85 years) compared to younger ones (21–40 years) [12]. Thus, a higher infection rate with HCoV-229E in older people and consequently the generation of neutralizing HCoV-229E–specific antibodies in the older plasma donors would explain the higher HCoV-229E titers found in IVIG lots produced from recovered plasma.