2.1.  Drug-likeness properties of the small molecules
The property of the small molecules for drug-likeness was estimated using the Lipinski’s rule (Lipinski et al., 2001). This rule works on five parameters viz. no more than five hydrogen bond donors, no more than 10 hydrogen bond acceptors, molecular mass <500 Da, and the octanol-water partition coefficient, i.e. log P should not exceed 5. The Lipinski’s parameters were obtained by using the SwissADME server (www.swissadme.ch/index.php) (Daina et al., 2017).