Whole-body autopsies offer several advantages over limited sampling using biopsies and tissues obtained post mortem [4–7]. Full-body autopsy studies of COVID-19 patients have been few due to several issues of infection control, and logistical and operational reasons. Whole-body autopsy allows examination of most body organs to define the extent of COVID-19 pathology, and also allows adequate tissue to be obtained for further pathological and molecular evaluation and for research purposes. They also allow a more accurate diagnosis to be made and minimize the chances of missing an accurate diagnosis due to sampling error. Supporting the call for action to conduct full autopsies on patients who die of COVID-19 for determining the extent of organ involvement [12, 13], we conducted a comprehensive postmortem full autopsy examination of 22 patients. To our knowledge, our study is the first to report pathological features of 4 cases of COVID-19 who did not have any prior underlying comorbidity or causes of immunosuppression.