TFPI: tissue factor pathway inhibitor; APC: activated protein C; rhAPC: recombinant human APC; tPA: tissue-type plasminogen activator; uPA: urokinase-type plasminogen activator; PAR-1: proteinase-activated receptor-1. #: trend towards reduced mortality in TFPI-treated group of community-acquired pneumonia patients who had not received concomitant heparin and in whom the pathogen was identified [40]; ¶: trend towards reduced mortality in TFPI group not receiving concomitant heparin [39]; +: trend towards reduced mortality in TFPI group (trial not powered for effect on mortality) [37]; §: difference in risk of major bleeding was not significant in those who did not receive concomitant heparin [47]; ƒ: no relevant studies were identified using this anticoagulant.