This case is the first description of a cranial polyneuropathy in a child infected with SARS‐CoV‐2. Neurological symptoms during the course of COVID19 have been reported in more than 35% cases in a recent study of 214 adult patients, 7  with three possible presentations: (a) central manifestations including dizziness, headache, ataxia, and seizure, (b) peripheral symptoms, like taste, smell, or vision impairment, and neuropathic pain, and (c) skeletal muscular failure. Of the 214 patients, only five presented isolated peripheral nerve damage. Six cases of Guillain‐Barré syndromes (GBS) occurring 5‐10 days after onset of COVID‐19 were recently described in adults, four of them presenting with facial paresia or diplegia. 8  One case of a 61‐year‐old was reported with complete GBS preceding typical COVID‐19 symptoms. 9  In children, a recent study described neurological signs with COVID‐19 affecting both central and peripheral nervous systems, without reported forms of cranial polyneuropathy. 10  Our observation is reminiscent of these reports, with some novel features: only craniofacial nerves were impaired, symptoms were presenting manifestations, and CSF never displayed a classic profile of GBS. The context of a heavily immunocompromised patient and the pre‐existing cerebral vasculopathy may explain these discrepancies, even though cranial polyneuropathy is not reported as a classic side effect of HSCT conditioning or sickle cell anemia. Viral co‐infections (EBV and HSV) may also have interplayed with SARS‐CoV‐2 in the pathogenesis of this polyneuropathy, although no concomitant replication could be documented.