Various infectious complications occurred around the date of transplant (day 0): Asymptomatic Epstein‐Barr virus (EBV) replication starting from day −14, treated with one rituximab infusion. Severe mucositis, aggravated by concomitant herpes simplex virus‐1 (HSV‐1) reactivation (oral and pelvic localizations), early after conditioning, treated with high dose acyclovir. Forty‐eight‐hour long febrile neutropenia during HSV‐1 reactivation, without other microbial documentation, treated with broad‐spectrum antibiotics (piperacillin‐tazobactam from day 0 to 20, vancomycine from day 2 to 15, ciprofloxacin from day 2 to 10).