A plethora of human and animal studies have investigated the beneficial effects of EPA and DHA in patients with ALI and ARDS which are common characteristics observed in severe SARS-CoV-2 patients (Messina et al., 2020; Nelson et al., 2003; Shirai, Yoshida, Matsumaru, Toyoda, & Ogura, 2015; Singer et al., 2006). Mancuso et al. demonstrated Long-Evans rats fed enteral diets containing fish oil as a source of n-3 PUFAs for 21 days were subjected to acute inflammation caused by an intravenous injection of Salmonella endotoxin. N-3 PUFA fed rats had a lower severity of pulmonary microvascular protein permeability and decreased pulmonary neutrophil accumulation compared to rats fed the n-6 PUFA enriched diet (Mancuso et al., 1997a; Mancuso et al., 1997b). Furthermore, stimulated alveolar macrophages had lower concentrations of AA-derived metabolites, such as thromboxane B2 (TxB2) and prostaglandin E2 (PGE2) suggesting a beneficial effect of n-3 PUFAs over n-6 PUFAs in attenuation of ALI (Mancuso et al., 1997a; Mancuso et al., 1997b). Saedisomeolia et al. demonstrated in Calu-3 epithelial cells infected with Rhinovirus RV-43 and RV-1B that pre-incubating with DHA significantly reduced the release of IL-6 and IFN-γ-inducible protein, suppressing RV-induced inflammation (Saedisomeolia, Wood, Garg, Gibson, & Wark, 2009). Collectively, these studies demonstrate that the anti-inflammatory properties of n-3 PUFAs play a pivotal role in attenuating the uncontrolled immune response in the lungs secondary to bacterial or viral infections which could be helpful in the setting of COVID-19.