• Phase 2: Low dose sarilumab i.v.
• Phase 2: Mid-dose sarilumab i.v.
• Phase 3 Cohort 1: Low dose sarilumab i.v.
• Phase 3 Cohort 1: Mid-dose sarilumab i.v.
• Phase 3 Cohort 2: High dose sarilumab i.v.
• Placebo given to match sarilumab administration