This work was supported by a grant from 10.13039/501100000024Canadian Institutes of Health Research (FRN 156393) to J.M.S. A.D. is supported by both an 10.13039/501100009192Alberta Innovates Graduate Studentship in Health Innovation and by the Izaak Walton Killam Memorial Scholarship. W.B. is supported by an 10.13039/501100009192Alberta Innovates Graduate Student Scholarship.