In this review we highlight the different mechanisms of cardiovascular complications secondary to COVID-19 and draw attention toward the potential roles n-3 PUFAs in mitigating these cardiovascular complications. Currently, there is no direct evidence of any beneficial or deleterious effect of n-3 PUFAs in COVID-19 patients. However, it is evident from the preceding discussion the dietary or non-dietary intake of n-3 PUFAs and/or their biologically active metabolites have many beneficial actions leading to prevention and management of cardiovascular complications. N-3 PUFAs and/or their biologically active metabolites have the potential to modulate many of the adverse effects of an exaggerated immune response, inactivate enveloped viruses, enhance macrophage phagocytic capacity, ameliorate coagulopathy, modify cell signaling and gene expression, shift the pattern of the lipid metabolites produced under stress conditions to a more anti-inflammatory metabolite profile and enhance the anti-oxidative capacity of the heart. Despite these promising effects of n-3 PUFAs, more experimental, randomized control trials and epidemiological research is warranted to test and translate these proposed effects in the setting of SARS-CoV-2 infection.