Patients with comorbidities such as diabetes, dyslipidemia, aberrations in plasma cholesterol and triglycerides and coronary heart disease are more susceptible to severe COVID-19 outcomes such as cardiac complications, sepsis, ARDS and death (Chen et al., 2020; Petersen et al., 2020; Shi et al., 2020; Wang, Hu, et al., 2020; Zhou, Yu, et al., 2020). The acute inflammatory syndrome associated with COVID-19 has the capacity to destabilize plaques, which can lead to ischemic events (Madjid et al., 2007). Recent studies indicated serum triglyceride concentrations were significantly higher in individuals who died as a result of COVID-19 likely due to augmented inflammatory TNF-α levels causing reduced lipoprotein lipase activity (Chen, Wu, et al., 2020; Skevaki, Fragkou, Cheng, Xie, & Renz, 2020). Triglyceride-glucose index, a product of fasting triglyceride and fasting plasma glucose levels, is used as a surrogate marker for insulin resistance (Ren et al., 2020). COVID-19 patients with a higher triglyceride-glucose index have been shown to experience more severe COVID-19 infection and death. Furthermore, levels of high density lipoprotein cholesterol (HDL-c) are also reduced in COVID-19 patients with the magnitude of reduction correlating with disease severity (Hu, Chen, Wu, He, & Ye, 2020). Generally, HDL-c is considered to be anti-inflammatory and antithrombotic (Suzuki et al., 2010; van der Stoep, Korporaal, & Van Eck, 2014). So, the robust, maladaptive inflammatory and hypercoagulability responses observed in more severe COVID-19 cases could possibly be attributed– in part – to reduced levels of HLD-c and a dysregulated lipid profile. Given the potential for COVID-19 infection to alter the lipid profile acutely and the association of dyslipidemia with conditions such as diabetes, coronary artery disease, and obesity raises the question whether normalization of plasma lipid profiles in COVID-19 patients can offer clinical benefit.