Lastly, using the PubMed search engine, we performed a literature search on 3 May 2020 with no time limitations for all articles in English, using different combinations of the terms Coronavirus, COVID, SARS-CoV-2, ACE2, stroke, and large vessel occlusion. Abstracts were screened to determine if the study matched our requirements. Then the full-text was read indepth, to determine the correlation between viral infection and stroke, and outcomes of ischemic stroke due to large vessel occlusion in the setting of COVID-19. We excluded manuscripts that had grouped transient ischemic attack, small vessel occlusion or hemorrhagic stroke with LVO, as it was not possible to identify the details for patients with LVO.