Despite timely intervention and favorable reperfusion, the mortality rate in COVID-19 with LVO was high in our series and higher in the pooled analysis. Younger age group, the involvement of both the arterial and venous vasculature, multivessel involvement, and complicated procedures due to the clot consistency and burden are notable features. The virus, through direct and indirect factors, creates a milieu that is proischemic and inhibits neuroprotective factors.