Author contributions YQQ, XC designed the study; YHY and MYZ performed the data collection; JYL and RL analyzed the data; XC drafted the manuscript; YQQ revised the manuscript. All authors read and approved the final manuscript. Funding This work was supported by the fund from New Coronavirus Pneumonia emergency research project of Shandong University (2020XGA02). Data Accessibility Publicly available databases were analyzed in our study. The active ingredients and putative target genes of SFJDC from TCMSP can be found in http://tcmspw.com/tcmsp.php. NCP-related target genes were from GeneCards (https://www.genecards.org/). Abbreviations ACE2 Angiotensin converting enzyme 2 ARDS acute respiratory distress syndrome BBB blood-brain barrier BC Betweenness Centrality BP biological processes Caco-2 Caco-2 permeability CC cellular components CC Colseness Centrality CG candidate genes DC Degree Centrality DL drug-likeness (DL) EC Eigenvector Centrality FF Forsythiae Fructus GO Gene Ontology HP Herba Patriniae I licorice IR Isatidis Radix KEGG Kyoto Encyclopedia of Genes and Genomes LAC Local average connectivity-based method LHQWG LianHua QingWen granules MF molecular functions NC Network Centrality NCP Novel Coronavirus Pneumonia OB oral bioavailability PCRR Polygoni Cuspidati Rhizoma Et Radix PPI protein-protein interaction PR Phragmitis Rhizoma RB Radix Bupleuri SFJDC ShuFeng JieDu capsule SARS-COV-2 Severe Acute Respiratory Syndrome-Coronavirus-2 TCM Traditional Chinese Medicine TCMSP Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform VH Verbenae Herb