Solvent casting is a prominent method used to prepare solid dispersion as an oral film where the cast solution is dried and cut into the desired size (16). This method is widely used to improve the dissolution of poorly water-soluble drugs and, therefore, to enhance their bioavailability in the body (17). Pharmaceutical film improvement in dissolution rate is often due to the use of hydrophilic polymers which cause an increase in solubilization effect of carrier (18). Furthermore, solid dispersions lead to a drug particle size reduction, improving drug wettability (19). In solid dispersion formulation, a key element is the morphological structure of compounds that could be either amorphous or crystalline affecting release profile of API from formulation (20). Modica de Mohac et al., in 2020, described as the different morphological structure could influence release profile and, therefore, important in polymer selection while improvement in release profile is sought (21). Mainly, crystalline and amorphous drugs present different enthalpy, entropy, and free energy that affect stability and dissolution rate of final dosage form (22). Amorphous materials show weaker attractive intermolecular forces that are more easily broken compared to crystalline counterparts, resulting in more soluble material and having a faster dissolution rate (20). However, several studies have shown that the formulation of solid microcrystalline dispersions could both improve dissolution rate and dosage form stability (16,23).