The DLPFC has been the usual cortical target for tDCS to prevent and ameliorate the consequences of psychosocial stress (Figure 1). Carnevali et al. (2020) recently postulated that the effects of tDCS may involve both a cognitive control of stress and the autonomic system, involving predominantly parasympathetic (vagal) responses (Carnevali et al., 2020). Further research is needed, however, to determine whether tDCS could prevent the consequences of repeated or persistent exposure to stressful situations such as in the context of social isolation during a pandemic. In addition, the response to anodal 1.0 mA left DLPFC stimulation for 30 min can differ depending on individual anxiety traits (Sarkar et al., 2014), with individuals with high anxiety profiles improving performance in cognitive tests (Cohen's d = 0.82), as well as decreased cortisol levels (Cohen's d = 1.37) compared to sham stimulation, an effect that was not observed in subjects with low anxiety profiles. Therefore, assessing specific psychological traits at baseline could help determine which individuals would benefit more from the effects of tDCS.