There is growing interest and studies investigating the effects of tDCS in animal models of stress and humans with chronic and acute stress. Animal models have shown reversal (Adachi et al., 2012) and prevention (Fregni et al., 2018) of chronic-stress induced pain after tDCS. In addition, tDCS was also able to decrease anxiety-like behaviors in rats submitted to neuropathic pain as a chronic stressor model (Marques Filho et al., 2016).