PMC:7523471 / 38569-39413
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7523471","sourcedb":"PMC","sourceid":"7523471","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7523471","text":"ADtg animals typically express the transmembrane amyloid precursor protein (APP), the source of Aβ protein, in retinal neurons. Indeed, this protein has been found in the retinas of ADtg drosophila, various ADtg mice (Tg2576, hTgAPPtg/tg, APPSWE/PS1 ΔE9, and APPSWE/PS1M146L/L286V), and the naturally occurring sporadic rodent strain Octodon degus (O. degus) (Ning et al., 2008; Dutescu et al., 2009; Liu et al., 2009; Ardiles et al., 2012; Du et al., 2015). Retinal cytoplasmic APP was found to increase in ADtg models (Ning et al., 2008; Dutescu et al., 2009), but decrease in the sporadic O. degus with aging (Du et al., 2015). Ning and colleagues found APP immunoreactivity increased with age in cells of the INL and GCL – but not the ONL – as well as the neuropil of the IPL and OPL and the outer segments (OS) and RPE (Ning et al., 2008).","tracks":[{"project":"TEST0","denotations":[{"id":"33041751-21-29-816478","span":{"begin":373,"end":377},"obj":"[\"18566467\"]"},{"id":"33041751-43-51-816479","span":{"begin":395,"end":399},"obj":"[\"19271231\"]"},{"id":"33041751-61-69-816480","span":{"begin":413,"end":417},"obj":"[\"19834067\"]"},{"id":"33041751-83-91-816481","span":{"begin":435,"end":439},"obj":"[\"22869717\"]"},{"id":"33041751-100-108-816482","span":{"begin":452,"end":456},"obj":"[\"26267479\"]"},{"id":"33041751-75-83-816483","span":{"begin":534,"end":538},"obj":"[\"18566467\"]"},{"id":"33041751-97-105-816484","span":{"begin":556,"end":560},"obj":"[\"19271231\"]"},{"id":"33041751-165-173-816485","span":{"begin":624,"end":628},"obj":"[\"26267479\"]"},{"id":"33041751-207-215-816486","span":{"begin":838,"end":842},"obj":"[\"18566467\"]"}],"attributes":[{"subj":"33041751-21-29-816478","pred":"source","obj":"TEST0"},{"subj":"33041751-43-51-816479","pred":"source","obj":"TEST0"},{"subj":"33041751-61-69-816480","pred":"source","obj":"TEST0"},{"subj":"33041751-83-91-816481","pred":"source","obj":"TEST0"},{"subj":"33041751-100-108-816482","pred":"source","obj":"TEST0"},{"subj":"33041751-75-83-816483","pred":"source","obj":"TEST0"},{"subj":"33041751-97-105-816484","pred":"source","obj":"TEST0"},{"subj":"33041751-165-173-816485","pred":"source","obj":"TEST0"},{"subj":"33041751-207-215-816486","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"33041751-18566467-38666264","span":{"begin":373,"end":377},"obj":"18566467"},{"id":"33041751-19271231-38666265","span":{"begin":395,"end":399},"obj":"19271231"},{"id":"33041751-19834067-38666266","span":{"begin":413,"end":417},"obj":"19834067"},{"id":"33041751-22869717-38666267","span":{"begin":435,"end":439},"obj":"22869717"},{"id":"33041751-26267479-38666268","span":{"begin":452,"end":456},"obj":"26267479"},{"id":"33041751-18566467-38666269","span":{"begin":534,"end":538},"obj":"18566467"},{"id":"33041751-19271231-38666270","span":{"begin":556,"end":560},"obj":"19271231"},{"id":"33041751-26267479-38666271","span":{"begin":624,"end":628},"obj":"26267479"},{"id":"33041751-18566467-38666272","span":{"begin":838,"end":842},"obj":"18566467"}],"attributes":[{"subj":"33041751-18566467-38666264","pred":"source","obj":"2_test"},{"subj":"33041751-19271231-38666265","pred":"source","obj":"2_test"},{"subj":"33041751-19834067-38666266","pred":"source","obj":"2_test"},{"subj":"33041751-22869717-38666267","pred":"source","obj":"2_test"},{"subj":"33041751-26267479-38666268","pred":"source","obj":"2_test"},{"subj":"33041751-18566467-38666269","pred":"source","obj":"2_test"},{"subj":"33041751-19271231-38666270","pred":"source","obj":"2_test"},{"subj":"33041751-26267479-38666271","pred":"source","obj":"2_test"},{"subj":"33041751-18566467-38666272","pred":"source","obj":"2_test"}]},{"project":"0_colil","denotations":[{"id":"33041751-18566467-816478","span":{"begin":373,"end":377},"obj":"18566467"},{"id":"33041751-19271231-816479","span":{"begin":395,"end":399},"obj":"19271231"},{"id":"33041751-19834067-816480","span":{"begin":413,"end":417},"obj":"19834067"},{"id":"33041751-22869717-816481","span":{"begin":435,"end":439},"obj":"22869717"},{"id":"33041751-26267479-816482","span":{"begin":452,"end":456},"obj":"26267479"},{"id":"33041751-18566467-816483","span":{"begin":534,"end":538},"obj":"18566467"},{"id":"33041751-19271231-816484","span":{"begin":556,"end":560},"obj":"19271231"},{"id":"33041751-26267479-816485","span":{"begin":624,"end":628},"obj":"26267479"},{"id":"33041751-18566467-816486","span":{"begin":838,"end":842},"obj":"18566467"}],"attributes":[{"subj":"33041751-18566467-816478","pred":"source","obj":"0_colil"},{"subj":"33041751-19271231-816479","pred":"source","obj":"0_colil"},{"subj":"33041751-19834067-816480","pred":"source","obj":"0_colil"},{"subj":"33041751-22869717-816481","pred":"source","obj":"0_colil"},{"subj":"33041751-26267479-816482","pred":"source","obj":"0_colil"},{"subj":"33041751-18566467-816483","pred":"source","obj":"0_colil"},{"subj":"33041751-19271231-816484","pred":"source","obj":"0_colil"},{"subj":"33041751-26267479-816485","pred":"source","obj":"0_colil"},{"subj":"33041751-18566467-816486","pred":"source","obj":"0_colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#bfec93","default":true},{"id":"2_test","color":"#ec93d9"},{"id":"0_colil","color":"#93ece5"}]}]}}