Hallmarks  Animal species  Models and Genotypes  Retinal pathologies  References
APP or Aβ related  Drosophila  AβPP, dBACE-AβPPL, pGMR-Aβ42  Increased APP, Aβ, Aβ42 toxicity  Finelli et al., 2004; Greeve et al., 2004; Carmine-Simmen et al., 2009; Cutler et al., 2015
Mouse  Tg2576, hTgAPPtg/tg, APPSWE/PS1ΔE9, APPSWE/PS1M146L/L286V, 3xTg, 5xFAD, Tg-SwDI  Increased APP, Aβ deposits, Aβ42, Aβ40, vascular Aβ, Aβ oligomers  Ning et al., 2008; Dutescu et al., 2009; Liu et al., 2009; Perez et al., 2009; Alexandrov et al., 2011; Koronyo-Hamaoui et al., 2011; Koronyo et al., 2012; Williams et al., 2013; Yang et al., 2013; Zhao et al., 2013; Edwards et al., 2014; He et al., 2014; Park et al., 2014; Gao et al., 2015; More and Vince, 2015; Parthasarathy et al., 2015; Pogue et al., 2015; Gupta et al., 2016; Oliveira-Souza et al., 2017; Criscuolo et al., 2018; Hadoux et al., 2019; Habiba et al., 2020; Sidiqi et al., 2020
O. degus  Spontaneous  Increased APP, Aβ, Aβ oligomers  Inestrosa et al., 2005; Ardiles et al., 2012; Du et al., 2015
Rat  TgF344-AD  Increased Aβ  Tsai et al., 2014
NFT or pTau related  Drosophila  hTau  Accumulation of pTau  Grammenoudi et al., 2006; Chouhan et al., 2016
Mouse  Tg2576, APPSWE/PS1 ΔE9, APPSWE/PS1M146L/L286V, 3xTg, P301S, rTg4510  Accumulation of pTau, NFT  Liu et al., 2009; Schön et al., 2012; Yang et al., 2013; Zhao et al., 2013; Chiasseu et al., 2017; Grimaldi et al., 2018; Harrison et al., 2019
O. degus  Spontaneous  Accumulation of pTau  Du et al., 2015; Chang et al., 2020