PMC:7523471 / 34690-35501 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7523471","sourcedb":"PMC","sourceid":"7523471","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7523471","text":"Overall, it is apparent that investigations of retinal Aβ pathology and its relationship with cerebral amyloid plaque burden in AD patients are mounting. However, our understanding of retinal pTau accumulation and associations with brain NFT severity is much more limited. To date, only a few groups have successfully detected tau hyperphosphorylation in post-mortem human retinas from AD patients, and only one study has shown an association between retinal pTau and cerebral amyloid load in a small number of AD patients. Therefore, there is an urgent need for systematic and quantitative analyses of retinal pTau in larger cohorts as well as assessment of both the spatiotemporal and pathomechanistic properties of AD-related tau species in the retina and their relationship with brain disease and cognition.","tracks":[]}