Aging remains the principal risk factor in AD and is tightly associated with several visual impairments. To date, only two studies have investigated the relationship between aging and total tau expression in the human retina. An early semi-quantitative analysis found no difference between tau immunoreactivity in post-mortem retinas from young and old healthy subjects, although age ranges were not clearly outlined (Loffler et al., 1995). Another study, examining retinas from enucleated eyes of patients with prior history of ocular disorders, reported a positive correlation between aging and total tau levels in RGCs in a subset of patients, while unable to find evidence of pTau (Leger et al., 2011). Such reports further showcase the disparity in these findings and reiterate the need for replication of these studies. Notably, the effects of aging on the abnormal accumulation of pTau in retinas of healthy individuals and/or patients also remains unexplored.