Retinal disorders such as glaucoma and age-related macular degeneration (AMD) share a number of common features with AD retinal pathology including progressive deposition of protein aggregates, reactive gliosis and pro-inflammatory responses, metabolic dysfunction, oxidative stress, and retinal atrophy (Quigley, 1999; Naskar et al., 2002; Gupta et al., 2006; Guo et al., 2007; Tezel, 2011). In 2008, examination of retinal tauopathy in surgically removed tissue from human glaucoma cases revealed intense localization of AT8-positive pTau in horizontal cells residing in the OPL (Ibach et al., 2006; Gupta et al., 2008). It is hypothesized that the lateral arrangement of horizontal cell processes may predispose them to retinal stretch injury caused by glaucoma-related elevated intraocular pressure (IOP). Although no association was found between high IOP and dementia (Cesareo et al., 2015), it remains to be seen whether similar changes occur due to AD-associated ocular abnormalities. However, increased retinal pTau accumulation and atrophy following injury or due to other neurodegenerative disorders reveal the vulnerability of this neural tissue compartment to structural, functional, and neuropathological abnormalities (Green et al., 2010; Leger et al., 2011; Kim et al., 2017; Satue et al., 2017; Behbehani et al., 2018; Kim et al., 2019).