Among CM patients with baseline MO, significantly greater proportions of patients treated with fremanezumab quarterly or monthly reverted to no MO during the 12-week treatment period (quarterly 111/201 [55.2%], P = 0.0389; monthly 120/198 [60.6%], P = 0.0024) than those who received placebo (87/188 [46.3%]) (Fig. 3). This effect was present by week 4 (quarterly 102/201 [50.7%], monthly 107/198 [54.0%] vs placebo 73/188 [38.8%]).
Fig. 3 Proportion of patients with CM who reverted from MO to no MO during the 12-week treatment period. CM, chronic migraine; MO, medication overuse